Avalide: Comprehensive Blood Pressure Control in One Tablet
| Product dosage: 162.5mg | |||
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Synonyms | |||
Avalide combines two proven antihypertensive agents—irbesartan and hydrochlorothiazide—into a single, convenient tablet designed for patients requiring multiple medications to achieve blood pressure goals. This fixed-dose combination therapy targets the renin-angiotensin-aldosterone system and promotes diuresis, offering a synergistic approach to hypertension management. It is indicated when monotherapy provides insufficient control, streamlining treatment regimens and potentially improving adherence. Clinical studies demonstrate significant reductions in both systolic and diastolic blood pressure with well-tolerated side effect profiles. Healthcare providers value its dual-mechanism action for patients with moderate to severe hypertension.
Features
- Contains irbesartan (an angiotensin II receptor blocker) and hydrochlorothiazide (a thiazide diuretic)
- Available in strengths: irbesartan/hydrochlorothiazide 150 mg/12.5 mg, 300 mg/12.5 mg, and 300 mg/25 mg
- Oral tablet formulation for once-daily dosing
- White to off-white, biconvex, and film-coated
- Manufactured under strict pharmaceutical quality standards
- Prescription-only medication requiring healthcare supervision
Benefits
- Provides dual-mechanism action for enhanced blood pressure reduction
- Simplifies treatment by combining two medications into a single tablet
- May improve medication adherence compared to multiple-pill regimens
- Demonstrates efficacy in diverse patient populations, including those with diabetes
- Reduces cardiovascular risk associated with uncontrolled hypertension
- Offers flexible dosing options to accommodate individual patient needs
Common use
Avalide is primarily prescribed for the treatment of hypertension in patients for whom combination therapy is appropriate. It is commonly used when blood pressure remains uncontrolled with either irbesartan or hydrochlorothiazide monotherapy. The medication may be particularly beneficial for patients with hypertension and type 2 diabetes with nephropathy, as irbesartan has demonstrated renal protective effects. Healthcare providers often initiate Avalide after assessing patient response to individual components or when anticipating the need for multiple antihypertensive agents.
Dosage and direction
The recommended starting dose is one Avalide 150 mg/12.5 mg tablet once daily. dosage may be titrated up to Avalide 300 mg/25 mg once daily based on blood pressure response. For patients already stabilized on the individual components, the corresponding combination tablet may be substituted. The medication should be taken consistently, with or without food, at approximately the same time each day. dose adjustments may be necessary for patients with renal impairment or hepatic dysfunction. Elderly patients may require lower initial doses. Regular blood pressure monitoring is essential during dosage adjustments.
Precautions
Patients should be monitored for electrolyte imbalances, particularly hypokalemia, hyponatremia, and hypomagnesemia. Regular assessment of renal function is recommended, especially in patients with pre-existing renal impairment or those taking NSAIDs. Hepatic function should be monitored in patients with liver disease. Caution is advised in patients with impaired renal function, as hydrochlorothiazide may precipitate azotemia. Patients with history of allergy or bronchial asthma may be at increased risk for hypersensitivity reactions. Photosensitivity reactions may occur due to hydrochlorothiazide component. Orthostatic hypotension may occur, particularly in volume-depleted patients.
Contraindications
Avalide is contraindicated in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or other sulfonamide-derived drugs. It is contraindicated in patients with anuria or severe renal impairment (CrCl <30 mL/min). Do not use in pregnancy, as drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus. Concomitant use with aliskiren in patients with diabetes is contraindicated. Avoid use in patients with refractory hypokalemia, hypercalcemia, or severe hepatic impairment.
Possible side effect
Common side effects include dizziness (8.1%), fatigue (3.5%), musculoskeletal pain (3.4%), and nausea/vomiting (2.8%). Less frequent adverse reactions may include orthostatic hypotension, hyperkalemia or hypokalemia, hyperuricemia, and impaired renal function. Rare but serious side effects include angioedema, pancreatitis, hepatic impairment, and blood dyscrasias. Hydrochlorothiazide component may cause photosensitivity, glucose intolerance, and increased cholesterol levels. Some patients may experience cough, although less frequently than with ACE inhibitors.
Drug interaction
Concomitant use with lithium increases lithium toxicity risk. NSAIDs may reduce antihypertensive effect and worsen renal function. Potassium-sparing diuretics or potassium supplements may increase hyperkalemia risk. Alcohol, barbiturates, or narcotics may potentiate orthostatic hypotension. Corticosteroids and ACTH increase electrolyte depletion risk. cholestyramine and colestipol may reduce hydrochlorothiazide absorption. diabetic medication requirements may be altered. Concomitant use with other antihypertensive agents may have additive effects.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is almost time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed. Patients should not take a double dose to make up for a missed dose. Consistent daily administration is important for maintaining blood pressure control. Patients should be advised to maintain a regular dosing routine and consider using reminder systems if missed doses become frequent.
Overdose
Symptoms of overdose may include hypotension, tachycardia, bradycardia, dizziness, decreased urinary output, and electrolyte imbalances. Severe overdose may lead to circulatory collapse, shock, and cardiac arrhythmias. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion was recent. intravenous normal saline may be administered for hypotension. electrolyte abnormalities should be corrected appropriately. Hemodialysis is not effective for irbesartan removal but may help eliminate hydrochlorothiazide. Close monitoring of vital signs and electrolyte status is essential.
Storage
Store at room temperature (20-25°C or 68-77°F) in the original container. Protect from light and moisture. Keep the bottle tightly closed when not in use. Do not store in bathroom or other humid areas. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly dispose of any unused or expired medication according to local regulations.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication regimen. The prescribing physician should be consulted for specific medical advice, diagnosis, and treatment. Individual patient responses may vary, and not all side effects or interactions are listed here. Full prescribing information should be reviewed before administration.
Reviews
Clinical studies demonstrate Avalide’s efficacy in reducing blood pressure, with many patients achieving target levels within 4-6 weeks of treatment. Healthcare providers report good patient tolerance and improved adherence compared to multiple-pill regimens. Some patients note convenient once-daily dosing and reduced pill burden. However, some reviews mention the need for regular monitoring of electrolyte levels and renal function. Overall, Avalide is considered an effective option for patients requiring combination therapy for hypertension management.