Azithromycin DT: Effective Bacterial Infection Treatment
Azithromycin Dispersible Tablets (DT) are a widely prescribed macrolide antibiotic designed to combat a broad spectrum of bacterial infections. This formulation offers the therapeutic efficacy of azithromycin with the added convenience of a dispersible tablet, which dissolves quickly in water for ease of administration. It is particularly valued in clinical practice for its high tissue penetration and once-daily dosing regimen, enhancing patient compliance. Healthcare professionals rely on its proven effectiveness against respiratory, skin, and sexually transmitted infections, making it a cornerstone in outpatient and inpatient treatment protocols.
Features
- Contains azithromycin dihydrate as the active ingredient
- Dispersible tablet formulation for easy ingestion without swallowing whole
- Available in strengths such as 250 mg and 500 mg
- Rapid dispersion in a small amount of water
- Stable under recommended storage conditions
- Manufactured under strict pharmaceutical quality standards
Benefits
- Effectively eradicates susceptible bacterial strains, leading to quicker symptom relief
- Convenient once-daily dosing improves adherence to treatment regimens
- Dispersible form is ideal for patients with swallowing difficulties, including pediatric and geriatric populations
- Broad-spectrum coverage targets common community-acquired infections
- Short treatment courses (often 3–5 days) due to extended half-life and tissue persistence
- Reduces risk of complication progression when used as directed
Common use
Azithromycin DT is indicated for the treatment of mild to moderate infections caused by susceptible strains of designated microorganisms. Common uses include bacterial exacerbations of chronic obstructive pulmonary disease (COPD), acute bacterial sinusitis, community-acquired pneumonia, pharyngitis/tonsillitis, uncomplicated skin and skin structure infections, and urethritis/cervicitis due to Chlamydia trachomatis. Off-label uses may include certain gastrointestinal infections and prophylaxis in specific clinical scenarios, under medical supervision.
Dosage and direction
Dosage must be individualized based on infection type, severity, and patient factors. For most infections in adults: 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2 through 5. Alternative regimen: 500 mg once daily for 3 days. For sexually transmitted infections: a single 1 g dose. Pediatric dosing is weight-based. The tablet should be dispersed in at least 50 mL of water, stirred, and the entire suspension consumed immediately. It may be taken with or without food, though administration with food may reduce gastrointestinal upset. Complete the full prescribed course even if symptoms improve earlier.
Precautions
Use with caution in patients with hepatic impairment; consider monitoring liver function. May prolong QT interval; avoid in patients with known QT prolongation, history of torsades de pointes, or concurrent use of other QT-prolonging drugs. There is a potential for Clostridium difficile-associated diarrhea. Use during pregnancy only if clearly needed; azithromycin crosses the placenta. Excreted in breast milk; weigh benefits against risks during lactation. Not recommended in patients with known hypersensitivity to macrolides. Superinfection with nonsusceptible organisms may occur.
Contraindications
Hypersensitivity to azithromycin, erythromycin, or any other macrolide or ketolide antibiotics. History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use. Concurrent use with ergot derivatives or drugs that significantly prolong QT interval, such as pimozide. Severe renal impairment (CrCl <10 mL/min) has not been studied; use is not recommended.
Possible side effect
Common: diarrhea, nausea, abdominal pain, vomiting. Less common: headache, dizziness, rash, elevated liver enzymes. Rare: QT prolongation, torsades de pointes, hepatotoxicity, Clostridium difficile-associated diarrhea, allergic reactions including angioedema and anaphylaxis (seek immediate medical attention if these occur). Most side effects are mild to moderate and self-limiting.
Drug interaction
May interact with antacids containing aluminum or magnesium (reduce azithromycin absorption; administer at least 2 hours apart). Increases concentration of drugs metabolized by CYP3A4 (e.g., cyclosporine, tacrolimus, ergot alkaloids, some statins). Concurrent use with warfarin may potentiate anticoagulant effect; monitor INR. QT-prolonging agents (e.g., antipsychotics, antiarrhythmics) may have additive effects. Nelfinavir increases azithromycin levels; monitor for side effects.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consult a healthcare provider if uncertain.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and hearing loss. Management is supportive; gastric lavage may be considered if ingestion was recent. There is no specific antidote. Hemodialysis is not effective. Contact a poison control center or seek emergency medical attention immediately.
Storage
Store at room temperature (15–30°C) in a dry place, protected from light and moisture. Keep the blister pack intact until use. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or changing your treatment plan. The manufacturer and distributor are not liable for any outcomes resulting from the use or misuse of this product.
Reviews
“Azithromycin DT has been a reliable choice in my practice for respiratory infections. The dispersible form is especially useful for elderly patients.” – Dr. A. Kumar, MD
“Effective and well-tolerated in most pediatric cases I’ve treated. Compliance is higher with the short course.” – Dr. L. Lopez, Pediatrician
“Rapid clinical response in skin infection cases. Convenient dosing benefits working adults.” – Dr. R. Smith, General Practitioner
“Occasional GI side effects, but overall a trusted antibiotic in our formulary.” – Clinical Pharmacist, Community Hospital
“Used according to guidelines, it minimizes resistance concerns. An essential tool against common pathogens.” – Infectious Disease Specialist