Casodex: Advanced Androgen Blockade for Prostate Cancer Control
| Product dosage: 50mg | |||
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Synonyms
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Casodex, with its active ingredient bicalutamide, is a non-steroidal anti-androgen medication specifically designed for the treatment of prostate cancer. It works by blocking the effects of androgens, such as testosterone, which can fuel the growth of prostate cancer cells. This targeted approach helps in controlling disease progression, often in combination with other therapies like LHRH analogues, providing a crucial component in the management of both localized and advanced stages of the condition. Its well-established efficacy and tolerability profile make it a trusted choice for clinicians and patients navigating prostate cancer treatment.
Features
- Contains bicalutamide as the active pharmaceutical ingredient
- Available in 50 mg film-coated tablets
- Designed for once-daily oral administration
- Exhibits high affinity for androgen receptors
- Manufactured under strict quality control standards
- Typically supplied in blister packs of 28 tablets
Benefits
- Effectively slows the progression of prostate cancer by inhibiting androgen-stimulated tumor growth
- Helps reduce prostate-specific antigen (PSA) levels, a key marker in monitoring disease status
- Can be used in combination therapy to enhance overall treatment efficacy
- Generally well-tolerated with a manageable side effect profile for many patients
- Supports improved quality of life by controlling cancer-related symptoms
- Offers convenience with once-daily dosing, promoting adherence to treatment regimens
Common use
Casodex is primarily indicated for the treatment of advanced prostate cancer, either as a monotherapy or, more commonly, in combination with a luteinizing hormone-releasing hormone (LHRH) analogue. It is used in both metastatic and non-metastatic settings to achieve maximal androgen blockade. In some cases, it may also be utilized as an adjuvant therapy following primary treatments like prostatectomy or radiotherapy, depending on the patient’s risk profile and the clinician’s assessment.
Dosage and direction
The standard adult dosage for Casodex is one 50 mg tablet taken orally once daily. It is typically administered in combination with an LHRH analogue, and the timing should align as per the prescribing physician’s instructions. Tablets should be swallowed whole with a glass of water, with or without food, though consistency in administration relative to meals is advised. Treatment duration is determined by the treating oncologist based on disease response, tolerability, and overall treatment strategy. Dosage adjustments are not usually required for elderly patients, but renal or hepatic impairment may necessitate careful monitoring and potential modification.
Precautions
Patients should be monitored regularly for liver function abnormalities, as hepatotoxicity has been reported. Periodic liver enzyme tests are recommended, especially within the first several months of therapy. Caution is advised in patients with moderate to severe hepatic impairment. Additionally, regular monitoring of PSA levels is essential to assess treatment response. Patients should avoid abrupt discontinuation without medical supervision. Use with caution in those with cardiovascular risk factors, as androgens can influence lipid profiles. It is important to note that Casodex may cause dizziness or visual disturbances; patients should refrain from driving or operating machinery if affected.
Contraindications
Casodex is contraindicated in patients with known hypersensitivity to bicalutamide or any excipients in the formulation. It must not be used in women, particularly those who are or may become pregnant, due to potential teratogenic effects. It is also contraindicated in pediatric patients. Concomitant use with terfenadine, astemizole, or cisapride is not recommended due to potential interactions. Patients with severe hepatic impairment should generally avoid this medication unless under strict specialist supervision with intensive monitoring.
Possible side effects
Common side effects may include hot flashes, breast tenderness or enlargement, nausea, constipation, diarrhea, and asthenia. Less frequently, patients may experience dizziness, dyspnea, peripheral edema, or rash. Hepatic changes, such as elevated transaminases or jaundice, have been observed and require prompt medical attention. Rare but serious adverse effects can include interstitial lung disease, heart failure, and severe cutaneous reactions. Most side effects are manageable and often diminish over time, but any persistent or severe symptoms should be reported to a healthcare provider.
Drug interaction
Casodex is primarily metabolized by CYP3A4; co-administration with strong inhibitors of this enzyme (e.g., ketoconazole, ritonavir) may increase bicalutamide plasma concentrations. Inducers of CYP3A4 (e.g., rifampicin, carbamazepine) could reduce its efficacy. Caution is advised when used with other medications that prolong the QT interval. It may also interact with warfarin, potentiating its anticoagulant effect and necessitating closer monitoring of INR levels. Always inform the prescribing physician of all concomitant medications, including over-the-counter drugs and supplements.
Missed dose
If a dose of Casodex is missed, it should be taken as soon as remembered on the same day. However, if it is nearly time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended. Consistent daily administration is important for maintaining stable androgen blockade, so patients should strive to adhere to the prescribed regimen and use reminders if necessary.
Overdose
There is no specific antidote for Casodex overdose. Symptoms may be an extension of its known adverse effects, such as heightened gastrointestinal disturbances or dizziness. In cases of suspected overdose, seek immediate medical attention. Supportive and symptomatic treatment is advised, including monitoring of vital signs and providing appropriate care for any clinical manifestations. Gastric lavage or activated charcoal may be considered if ingestion was recent, though the benefit should be weighed against risks.
Storage
Store Casodex tablets at room temperature, between 15–30°C (59–86°F), in a dry place away from direct light and moisture. Keep the medication in its original packaging to protect from light and humidity. Ensure it is stored out of reach and sight of children and pets. Do not use beyond the expiration date printed on the packaging. Proper disposal of any unused or expired medication should follow local guidelines, typically via pharmacy take-back programs, to prevent environmental contamination or accidental ingestion.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations based on your individual health status and needs. Do not initiate, adjust, or discontinue any medication without guidance from a licensed medical professional. The manufacturer and distributors are not liable for any inaccuracies or misuse of this information.
Reviews
Clinical studies and patient reports generally reflect Casodex as an effective component in prostate cancer management, with many noting stabilized PSA levels and delayed disease progression. Some users report manageable side effects such as hot flashes, while others emphasize the importance of regular monitoring for liver function. Overall, it is regarded as a valuable option in androgen deprivation therapy, particularly when combined with other treatments. Individual experiences may vary, so ongoing communication with healthcare teams is essential to optimize therapeutic outcomes.