Combivir: Advanced Dual Therapy for HIV Management
| Product dosage: 150mg+300mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $2.89 | $86.69 (0%) | 🛒 Add to cart |
| 60 | $2.40 | $173.38 $144.15 (17%) | 🛒 Add to cart |
| 90 | $2.21 | $260.07 $198.58 (24%) | 🛒 Add to cart |
| 120 | $1.92 | $346.76 $229.83 (34%) | 🛒 Add to cart |
| 180 | $1.72 | $520.14 $310.47 (40%) | 🛒 Add to cart |
| 270 | $1.58 | $780.21 $426.40 (45%) | 🛒 Add to cart |
| 360 | $1.44
Best per pill | $1040.28 $517.12 (50%) | 🛒 Add to cart |
Combivir represents a cornerstone in antiretroviral therapy, combining two potent active ingredients into a single tablet to enhance treatment adherence and efficacy. This fixed-dose combination is specifically formulated for the treatment of Human Immunodeficiency Virus (HIV) infection in adults and children, streamlining complex regimens into a manageable daily routine. Its dual-action mechanism targets the virus at multiple stages, helping to suppress viral load and improve immune function. Trusted by healthcare professionals worldwide, Combivir is designed to support long-term viral suppression as part of a comprehensive HIV management strategy.
Features
- Contains 150 mg lamivudine and 300 mg zidovudine per tablet
- Fixed-dose combination for simplified dosing
- Film-coated, oval-shaped, white tablets
- Available in bottles of 60 tablets
- Requires prescription only
- Manufactured under strict quality control standards
Benefits
- Enhanced adherence: Reduces pill burden by combining two medications into one daily dose.
- Potent viral suppression: Dual mechanism effectively lowers HIV viral load.
- Immune system support: Helps increase CD4 cell counts over time.
- Proven efficacy: Backed by extensive clinical research and real-world use.
- Convenient dosing: Simplifies treatment regimen for better long-term management.
- Global accessibility: Widely available and included in many treatment guidelines.
Common use
Combivir is indicated for the treatment of HIV-1 infection in combination with other antiretroviral agents. It is used in both treatment-naïve and treatment-experienced patients, as determined by a healthcare provider based on viral resistance patterns and individual patient factors. It is suitable for adults and pediatric patients weighing at least 30 kg.
Dosage and direction
The recommended dosage for adults and adolescents (weighing at least 30 kg) is one tablet taken orally twice daily. It can be taken with or without food. For pediatric patients, dosing should be calculated based on body weight and must not exceed the adult dose. Always follow the specific instructions provided by the prescribing physician. Do not alter the dose without medical consultation.
Precautions
- Regular monitoring of blood counts is recommended due to the risk of hematological toxicity.
- Use with caution in patients with pre-existing bone marrow suppression or liver disease.
- Lactic acidosis and severe hepatomegaly with steatosis have been reported; discontinue use if these occur.
- Patients with hepatitis B co-infection should be closely monitored; exacerbation of hepatitis may occur upon discontinuation.
- Avoid use in patients with known hypersensitivity to lamivudine, zidovudine, or any component of the formulation.
Contraindications
Combivir is contraindicated in patients with:
- Known hypersensitivity to lamivudine, zidovudine, or any excipients in the formulation.
- Life-threatening allergic reactions to any components.
- Significantly reduced neutrophil counts (<0.75 x 10⁹/L) or hemoglobin levels (<7.5 g/dL or 4.65 mmol/L).
Possible side effects
Common side effects may include:
- Headache
- Nausea
- Fatigue
- Insomnia
- Musculoskeletal pain
Serious side effects requiring immediate medical attention:
- Lactic acidosis
- Severe hepatomegaly with steatosis
- Hematological toxicity (neutropenia, anemia)
- Myopathy
- Lipodystrophy
- Peripheral neuropathy
Drug interaction
Combivir may interact with:
- Stavudine: Antagonistic effects; concomitant use is not recommended.
- Ribavirin: Increased risk of lactic acidosis; avoid combination.
- Other myelosuppressive agents: Increased risk of hematological toxicity.
- Interferon-based therapies: Caution advised due to overlapping toxicities.
- Probenecid: May increase zidovudine levels.
- Medications affecting renal function: Dose adjustment may be needed.
Inform your healthcare provider of all medications, including prescription, over-the-counter, and herbal products.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Maintain the regular dosing schedule to ensure consistent antiviral activity.
Overdose
Symptoms of overdose may include fatigue, headache, nausea, vomiting, and hematological disturbances. There is no specific antidote; treatment is supportive and symptomatic. Hemodialysis may remove lamivudine but not zidovudine. In case of suspected overdose, seek immediate medical attention or contact a poison control center.
Storage
Store at room temperature (15–30°C or 59–86°F) in the original container. Keep the bottle tightly closed and protect from moisture. Do not use if the seal is broken or missing. Keep out of reach of children and pets. Do not flush unused medication; dispose of properly according to local guidelines.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and personalized medical guidance. Use only as prescribed; do not share medication with others.
Reviews
“Combivir has been a reliable part of my HIV regimen for years. The convenience of a combination tablet makes adherence much easier.” – Patient, 48
“As an infectious disease specialist, I value the proven efficacy and safety profile of Combivir in appropriate patient populations.” – Healthcare Provider
“Switching to Combivir simplified my daily routine without compromising on viral suppression.” – Patient, 34