Cyclogyl: Rapid and Reliable Mydriasis for Ophthalmic Examination
| Product dosage: 5 ml | |||
|---|---|---|---|
| Package (num) | Per bottle | Price | Buy |
| 2 | $9.02 | $18.04 (0%) | 🛒 Add to cart |
| 4 | $6.26 | $36.09 $25.06 (31%) | 🛒 Add to cart |
| 6 | $5.35
Best per bottle | $54.13 $32.08 (41%) | 🛒 Add to cart |
Synonyms | |||
Cyclogyl (cyclopentolate hydrochloride ophthalmic solution) is a fast-acting anticholinergic agent specifically formulated to induce mydriasis (pupil dilation) and cycloplegia (paralysis of the ciliary muscle) for diagnostic purposes. It is a cornerstone in ophthalmic practice, enabling detailed examination of the retina and lens, and accurate refractive error assessment. Its rapid onset and relatively short duration make it an efficient choice for clinicians seeking to minimize patient discomfort and downtime while obtaining critical diagnostic data.
Features
- Contains cyclopentolate hydrochloride as the active pharmaceutical ingredient
- Available in concentrations typically ranging from 0.5% to 2%
- Rapid onset of action, with mydriasis often beginning within 30 minutes
- Provides effective cycloplegia for refractive accuracy
- Formulated as a sterile ophthalmic solution
- Packaged in multi-dose dropper bottles for precise administration
Benefits
- Facilitates comprehensive fundoscopic examinations by providing clear, unobstructed views of the posterior segment
- Enables accurate determination of refractive errors by temporarily paralyzing accommodation
- Reduces examination time due to its quick onset of action
- Minimizes patient inconvenience with a relatively short duration of effect compared to longer-acting agents
- Supports early detection and management of ocular pathologies through improved diagnostic capability
- Enhances procedural efficiency in busy clinical settings
Common use
Cyclogyl is primarily employed in ophthalmology and optometry for diagnostic procedures. Its main applications include facilitating thorough examination of the retina, optic nerve, and lens during routine eye exams and specialized assessments. It is particularly valuable in pediatric ophthalmology for refractory testing in children, whose accommodative ability can significantly impact refractive measurements. The medication is also used preoperatively in cataract surgery and other ocular procedures to achieve adequate pupil dilation. Additionally, it may be employed in the management of certain inflammatory eye conditions where pupillary dilation helps prevent synechiae formation.
Dosage and direction
Administration should always follow the prescribing ophthalmologist’s specific instructions. For routine mydriasis and cycloplegia in adults, one to two drops of the 1% solution instilled into the conjunctival sac of each eye undergoing examination typically suffices. For pediatric patients or cases requiring deeper cycloplegia, the 2% solution may be employed with appropriate caution. Repeat instillation after 5-10 minutes may be necessary if adequate dilation is not achieved. Patients should avoid touching the dropper tip to any surface to maintain sterility. Following installation, gentle pressure should be applied to the lacrimal sac for 2-3 minutes to minimize systemic absorption. The eyes should remain closed for 1-2 minutes after administration to enhance local absorption.
Precautions
Cyclogyl should be used with particular caution in patients with known hypersensitivity to cyclopentolate or any component of the formulation. Special attention is required when administering to infants, children, and the elderly, as they may be more susceptible to systemic effects. Patients with Down’s syndrome, brain damage, or spastic paralysis may exhibit exaggerated responses to anticholinergic agents. Those with narrow-angle glaucoma or predisposition to angle closure require careful assessment before administration. Caution is advised in patients with cardiovascular disorders, gastrointestinal obstruction, or urinary retention. The solution may cause blurred vision and photophobia—patients should avoid driving or operating machinery until these effects subside.
Contraindications
Cyclogyl is contraindicated in patients with known hypersensitivity to cyclopentolate hydrochloride or any components of the formulation. It should not be used in patients with narrow-angle glaucoma or anatomically narrow angles without appropriate pretreatment. Contraindications include untreated open-angle glaucoma where mydriasis may potentially increase intraocular pressure. The medication is not recommended for patients with untreated megacolon or significant gastrointestinal obstructive diseases. Use is contraindicated in patients with unstable cardiovascular status or those experiencing acute hemorrhagic shock.
Possible side effect
Ocular side effects may include transient stinging or burning upon instillation, blurred vision, photophobia, and increased intraocular pressure. Conjunctival hyperemia, irritation, and allergic reactions may occur. Systemic absorption can rarely lead to anticholinergic effects including dry mouth, flushed skin, fever, tachycardia, urinary retention, and gastrointestinal disturbances. Central nervous system effects may include confusion, hallucinations, ataxia, and behavioral disturbances, particularly in children and the elderly. These symptoms typically resolve as the medication’s effects diminish but should be monitored closely.
Drug interaction
Concurrent use with other anticholinergic agents may potentiate both ocular and systemic effects. Monoamine oxidase inhibitors and tricyclic antidepressants may enhance the anticholinergic activity of cyclopentolate. Concomitant use with phenothiazines may increase the risk of adverse effects. The mydriatic effect may be reduced by concomitant administration of pilocarpine or other miotics. Patients taking medications with anticholinergic properties should inform their ophthalmologist before Cyclogyl administration.
Missed dose
As Cyclogyl is typically administered under professional supervision in clinical settings, missed doses are not generally a concern for patients. For prescribed home use (rare), if a dose is missed, it should be administered as soon as remembered unless it is nearly time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling doses to make up for missed administrations is not recommended.
Overdose
Overdosage may manifest as exaggerated anticholinergic symptoms including severe dry mouth, blurred vision, tachycardia, hot dry skin, difficulty urinating, and abdominal distention. Central nervous system effects may include confusion, hallucinations, and seizures. In case of suspected overdose, medical attention should be sought immediately. Treatment is primarily supportive and symptomatic. Activated charcoal may be administered if ingestion occurred recently. In severe cases, physostigmine may be considered under careful monitoring for cholinergic crisis.
Storage
Store Cyclogyl at controlled room temperature between 15-30°C (59-86°F). Protect from light and excessive heat. Keep the container tightly closed when not in use. Do not freeze the solution. Keep out of reach of children and pets. Discard any unused solution after the expiration date printed on the packaging. Do not use if the solution appears discolored or contains particles.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. The prescribing healthcare professional should be consulted for diagnosis and treatment of medical conditions. The complete prescribing information should be reviewed before administration. Individual patient responses may vary, and professional medical judgment should guide all treatment decisions.
Reviews
Ophthalmologists consistently report high satisfaction with Cyclogyl’s rapid onset and predictable duration of action. Many practitioners appreciate its reliability in achieving adequate cycloplegia for refractive measurements, particularly in pediatric patients. The relatively short duration of action is frequently cited as advantageous for clinical workflow efficiency. Some clinicians note the importance of proper nasolacrimal occlusion technique to minimize systemic effects. Overall, Cyclogyl remains a trusted agent in ophthalmic practice for diagnostic procedures requiring mydriasis and cycloplegia.