Duphalac is a well-established osmotic laxative containing lactulose, specifically formulated for the management of chronic constipation. It works by drawing water into the bowel, softening stools and stimulating bowel movements in a predictable and gentle manner. Trusted by healthcare professionals globally, Duphalac offers a reliable solution for both occasional and persistent constipation, promoting long-term bowel regularity with a favorable safety profile.

Features

• Contains lactulose as the active pharmaceutical ingredient
• Available in oral solution and sachet formulations for flexible dosing
• Osmotic mechanism of action ensures predictable results
• Sugar-free variants available for diabetic patients
• Pleasant taste for improved patient compliance, especially in pediatric and geriatric populations
• Manufactured under strict pharmaceutical quality control standards

Benefits

• Provides effective and reliable relief from constipation within 24–48 hours of administration
• Promotes the growth of beneficial gut bacteria (Bifidobacteria, Lactobacilli), supporting overall digestive health
• Helps restore and maintain regular bowel habits without causing harsh urgency or cramping
• Reduces the absorption of ammonia in the gut, making it beneficial in hepatic encephalopathy management
• Suitable for long-term use with minimal risk of tolerance or dependency
• Easy-to-administer liquid form is ideal for patients of all ages, including infants and the elderly

Common use

Duphalac is primarily indicated for the treatment of chronic and occasional constipation. It is also widely used in the management and prevention of hepatic encephalopathy—a complication of liver disease where toxins like ammonia accumulate in the bloodstream. Healthcare providers may recommend Duphalac for preoperative bowel preparation in specific cases, and it is often used in pediatric constipation under medical supervision.

Dosage and direction

For constipation in adults and adolescents: The usual starting dose is 15–30 ml (10–20 g of lactulose) daily, adjusted to individual response. Maintenance dose typically ranges from 10–25 ml daily.
For children: 5–10 ml daily for ages 7–14; 5 ml daily for ages 1–6. For infants under 1 year, consult a pediatrician.
For hepatic encephalopathy: Initial dose is 30–45 ml three to four times daily, then adjusted to produce 2–3 soft stools per day.
Administration: Should be taken orally, preferably with meals. Can be diluted with water or juice to improve palatability. Dosage should be individualized based on clinical response.

Precautions

Use with caution in patients with diabetes due to carbohydrate content (though sugar-free options are available). Electrolyte monitoring may be advisable during prolonged use in debilitated patients. If abdominal pain, nausea, or vomiting occurs, discontinue use and seek medical advice. Not recommended for use in patients requiring a low-galactose diet.

Contraindications

Duphalac is contraindicated in patients with galactosemia, intestinal obstruction, or hypersensitivity to any of its components. It should not be used in cases of undiagnosed abdominal pain, as it may exacerbate certain conditions.

Possible side effect

Common side effects may include flatulence, bloating, and abdominal discomfort, especially during the initial days of treatment. These usually subside as the body adjusts. Less frequently, diarrhea, nausea, or electrolyte imbalance may occur. Excessive doses can lead to abdominal cramping and significant diarrhea.

Drug interaction

No significant drug interactions have been widely reported. However, concomitant use with non-absorbable antacids may reduce the effect of Duphalac. Always inform your healthcare provider about all medications, including over-the-counter products and supplements.

Missed dose

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one.

Overdose

Overdose may lead to severe diarrhea and abdominal cramps. Treatment is supportive; ensure adequate hydration and electrolyte balance. In cases of significant dehydration, seek medical attention promptly.

Storage

Store below 25°C. Do not freeze. Keep the bottle tightly closed to prevent evaporation and contamination. Keep out of reach of children. Use within the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment recommendations, and personalized dosage instructions. Use only as directed.

Reviews

Clinical studies and patient reports consistently highlight Duphalac’s efficacy and tolerability. Many users appreciate its gentle action and reliability, particularly for long-term management of constipation. Healthcare professionals often recommend it due to its dual benefits in constipation and hepatic encephalopathy, noting its safety profile in diverse patient populations.