Flexeril (cyclobenzaprine hydrochloride) is a centrally acting skeletal muscle relaxant indicated as an adjunct to rest and physical therapy for the relief of muscle spasm associated with acute, painful musculoskeletal conditions. It works by acting on the central nervous system to reduce muscle hyperactivity, thereby alleviating discomfort and improving mobility. Clinical studies demonstrate its efficacy in providing symptomatic relief, making it a valuable option in short-term management protocols under professional supervision.

Features

• Active ingredient: Cyclobenzaprine hydrochloride
• Available in 5 mg and 10 mg oral tablets
• Onset of action typically within one hour
• Duration of effect: 4–6 hours per dose
• Prescription-only medication
• Manufactured under strict pharmaceutical quality standards

Benefits

• Rapid relief from acute muscle spasms and associated pain
• Improved range of motion and functional capacity during recovery
• Reduction in muscle stiffness and tenderness
• Facilitates participation in physical therapy and rehabilitation
• Short-term adjunctive therapy supporting overall treatment efficacy
• Minimizes discomfort from musculoskeletal injuries or strains

Common use

Flexeril is commonly prescribed for the short-term management of muscle spasms resulting from conditions such as strains, sprains, or other musculoskeletal injuries. It is used adjunctively with rest, physical therapy, and other measures to relieve discomfort and support recovery. It is not indicated for chronic or long-term use, nor for spasticity associated with cerebral or spinal cord conditions.

Dosage and direction

The usual adult dosage is 5 mg or 10 mg three times daily. Dosage may be adjusted based on individual response and tolerability, though the maximum recommended dose is 30 mg per day (10 mg three times daily). Use should not exceed two or three weeks due to lack of evidence of longer-term efficacy and increased risk of adverse effects. Tablets should be taken orally with or without food, as directed by a healthcare provider.

Precautions

Use with caution in patients with mild hepatic impairment; not recommended in moderate to severe impairment. May cause drowsiness or dizziness—avoid driving or operating machinery until effects are known. Elderly patients may be more sensitive to effects. Not recommended during pregnancy or breastfeeding unless clearly needed. Avoid alcohol and other CNS depressants. Discontinue if signs of allergic reaction occur.

Contraindications

Hypersensitivity to cyclobenzaprine or any component of the formulation. Concurrent use of monoamine oxidase (MAO) inhibitors or within 14 days of discontinuing MAO inhibitor therapy. Hyperthyroidism, congestive heart failure, arrhythmias, or recent myocardial infarction. Severe hepatic impairment.

Possible side effects

Common side effects may include drowsiness, dry mouth, dizziness, and fatigue. Less frequently, patients may experience headache, nausea, nervousness, or blurred vision. Serious side effects are rare but may include tachycardia, hypotension, syncope, seizures, or signs of allergic reaction such as rash, itching, or swelling. Discontinue and seek medical attention if severe reactions occur.

Drug interaction

May interact with MAO inhibitors, leading to serious adverse effects including hyperpyrexia and seizures. Potentiates effects of alcohol, sedatives, and other CNS depressants. Use with tramadol may increase seizure risk. Caution with anticholinergic drugs, tricyclic antidepressants, or other serotonergic drugs due to potential for serotonin syndrome.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Resume regular dosing schedule. Consult a healthcare provider with questions regarding missed doses.

Overdose

Symptoms may include severe drowsiness, tachycardia, tremor, agitation, confusion, hallucinations, or seizures. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Treatment is supportive and may include activated charcoal, ECG monitoring, and symptomatic care.

Storage

Store at room temperature (20–25°C or 68–77°F) in a tightly closed container. Protect from light and moisture. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical studies and patient reports indicate that Flexeril is generally well-tolerated and effective for short-term relief of acute muscle spasm. Many users report significant reduction in pain and spasm within the first few days of use. Drowsiness is a commonly noted side effect, often diminishing with continued use. It is important to use only as prescribed and for the duration recommended by a healthcare professional.