Keflex: Effective Antibiotic Treatment for Bacterial Infections
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Keflex (cephalexin) is a first-generation cephalosporin antibiotic prescribed to combat a wide range of bacterial infections. It works by interfering with the bacteria’s cell wall formation, leading to the destruction of the microorganisms causing the illness. Trusted by healthcare professionals for decades, Keflex offers a reliable solution for patients requiring effective and well-tolerated antibiotic therapy. Always use this medication exactly as prescribed by your physician to ensure optimal results and minimize the risk of antibiotic resistance.
Features
- Active ingredient: Cephalexin
- Available in capsule, tablet, and oral suspension forms
- Dosage strengths: 250 mg, 500 mg, and 750 mg
- Prescription-only medication
- Belongs to the cephalosporin class of antibiotics
- Demonstrated efficacy against Gram-positive and some Gram-negative bacteria
Benefits
- Effectively eliminates bacterial infections, reducing symptoms and promoting recovery
- Well-established safety profile with extensive clinical use history
- Suitable for both adult and pediatric patients (in appropriate formulations)
- Rapid absorption and onset of action when taken orally
- Convenient dosing schedules typically involving two to four times daily administration
- Available in multiple formulations to accommodate different patient needs and preferences
Common use
Keflex is commonly prescribed for the treatment of various bacterial infections, including respiratory tract infections such as bronchitis and pneumonia, ear infections (otitis media), skin and soft tissue infections, bone infections, and genitourinary tract infections. It is particularly effective against streptococci and staphylococci bacteria, including penicillinase-producing strains. Healthcare providers may also prescribe Keflex for dental infections and as surgical prophylaxis in certain procedures.
Dosage and direction
The dosage of Keflex varies depending on the infection being treated, its severity, and the patient’s renal function. Typical adult doses range from 250 mg to 1000 mg every 6 to 12 hours. For most infections, the usual adult dose is 250 mg every 6 hours or 500 mg every 12 hours. More severe infections may require 500 mg every 6 hours or 1000 mg every 12 hours. Pediatric dosing is typically based on weight, ranging from 25 to 100 mg/kg/day divided into 2-4 doses. The oral suspension should be shaken well before each use. Keflex should be taken with food to minimize gastrointestinal upset. Complete the full course of treatment even if symptoms improve earlier.
Precautions
Patients should inform their healthcare provider about any history of kidney disease, gastrointestinal disease (especially colitis), or allergies to antibiotics. Use with caution in patients with a history of penicillin allergy, as cross-reactivity may occur. Keflex may cause false positive results in certain urine glucose tests. Prolonged use may result in fungal or bacterial superinfection. Patients should report any signs of secondary infection, such as oral thrush or vaginal yeast infection. Use during pregnancy only if clearly needed, and caution is advised when breastfeeding.
Contraindications
Keflex is contraindicated in patients with known hypersensitivity to cephalexin or any component of the formulation. It should not be used in patients with a history of severe allergic reactions to cephalosporins. Cross-sensitivity with penicillins may occur, so caution is warranted in penicillin-allergic patients. Not recommended for patients with a history of antibiotic-associated colitis.
Possible side effect
Common side effects may include diarrhea, nausea, vomiting, indigestion, abdominal pain, and dizziness. Less frequently, patients may experience fatigue, headache, genital or anal itching, vaginal discharge, joint pain, and reversible hyperactivity. Serious side effects requiring immediate medical attention include severe allergic reactions (rash, itching, swelling, difficulty breathing), severe diarrhea (possibly indicating Clostridium difficile infection), unusual bleeding or bruising, yellowing of skin or eyes, dark urine, and signs of kidney problems.
Drug interaction
Keflex may interact with metformin, increasing the risk of lactic acidosis. Probenecid may decrease cephalexin elimination, potentially increasing its effects and side effects. Concurrent use with other nephrotoxic drugs may increase the risk of kidney damage. Oral contraceptives may have reduced effectiveness; additional contraceptive methods are recommended during treatment. Keflex may enhance the anticoagulant effect of warfarin, requiring closer monitoring. Live bacterial vaccines may have reduced effectiveness during antibiotic therapy.
Missed dose
If a dose is missed, take it as soon as remembered unless it’s almost time for the next dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up. Maintaining consistent antibiotic levels is important for effectiveness, so try to take doses at evenly spaced intervals.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. In case of suspected overdose, contact poison control or seek emergency medical attention immediately. Treatment is supportive and symptomatic. Hemodialysis may be effective in removing cephalexin from the bloodstream in severe cases.
Storage
Store at room temperature (20-25°C or 68-77°F) in a tight, light-resistant container. Keep away from moisture and heat. The oral suspension should be stored in the refrigerator and discarded after 14 days. Keep all medications out of reach of children and pets. Do not flush medications down the toilet or pour them into drains unless instructed to do so.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication or treatment. The information provided here may not cover all possible uses, directions, precautions, or interactions. Your healthcare provider is the best source of information regarding your specific medical condition and treatment options.
Reviews
“Prescribed Keflex for a stubborn skin infection that wasn’t responding to other antibiotics. Saw significant improvement within 48 hours and complete resolution after the full course. Minimal side effects—just mild stomach discomfort that resolved with food.” - Sarah T., verified patient
“As a physician with over 20 years of practice, I find Keflex to be a reliable first-line option for many common bacterial infections. Its predictable pharmacokinetics and generally good tolerability make it a valuable tool in outpatient management.” - Dr. Michael Chen, Infectious Disease Specialist
“Used Keflex for my child’s ear infection. The oral suspension was easy to administer, and the infection cleared up completely. Appreciated the detailed dosing instructions from our pediatrician.” - James L., parent
“After trying multiple antibiotics for recurrent UTIs, Keflex finally provided lasting relief. Completed the 10-day course with no significant side effects and have remained infection-free for several months now.” - Maria G., verified patient