Plendil: Advanced Blood Pressure Control for Cardiovascular Health
| Product dosage: 5mg | |||
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Synonyms | |||
Plendil (felodipine) is a calcium channel blocker prescribed for the management of hypertension. It functions by relaxing blood vessels, facilitating smoother blood flow and reducing cardiac workload. This medication is designed for long-term use, aiding in the prevention of heart attacks, strokes, and kidney problems associated with uncontrolled high blood pressure. Clinical evidence supports its efficacy in both monotherapy and combination treatment regimens, offering a reliable option for sustained cardiovascular protection.
Features
- Active ingredient: Felodipine
- Drug class: Dihydropyridine calcium channel blocker
- Available in extended-release tablet formulations (2.5 mg, 5 mg, 10 mg)
- Once-daily dosing for consistent 24-hour therapeutic coverage
- Designed to minimize peak-trough fluctuations in plasma concentration
Benefits
- Effectively lowers systolic and diastolic blood pressure, reducing strain on the heart and arteries.
- Decreases the risk of major cardiovascular events, including myocardial infarction and stroke.
- Supports preservation of kidney function by maintaining optimal renal perfusion pressure.
- Improves exercise tolerance and reduces angina symptoms in patients with concomitant coronary artery disease.
- Offers a favorable side effect profile with a low incidence of metabolic disturbances.
- Provides flexible dosing options suitable for combination therapy with other antihypertensive agents.
Common use
Plendil is primarily indicated for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive drugs. It may also be used off-label for certain cases of chronic stable angina pectoris. Physicians often prescribe it for patients who require vasodilation without significantly affecting heart rate or cardiac conduction. It is particularly beneficial for elderly hypertensive patients and those with isolated systolic hypertension.
Dosage and direction
The recommended initial dose for most adults is 5 mg once daily, which may be adjusted based on therapeutic response and tolerability. Dosage adjustments should occur at intervals not shorter than 2 weeks. The maintenance dose typically ranges from 2.5 mg to 10 mg daily. Tablets should be swallowed whole, not crushed or chewed, and may be taken with or without food—though consistent administration with a light meal may help reduce gastrointestinal irritation. For patients with hepatic impairment or elderly patients, initiation at 2.5 mg daily is advised.
Precautions
Patients should be monitored for signs of hypotension, especially during initial titration or when combining with other antihypertensives. Peripheral edema may occur and is dose-dependent. Use with caution in patients with heart failure or severe aortic stenosis. Regular blood pressure monitoring and periodic assessment of liver function are recommended. Patients should avoid grapefruit juice, as it may increase felodipine plasma concentrations. Abrupt withdrawal should be avoided to prevent rebound hypertension.
Contraindications
Plendil is contraindicated in patients with known hypersensitivity to felodipine or any component of the formulation. It should not be used in patients with severe hypotension or cardiogenic shock. The safety and efficacy of Plendil have not been established in children, and it is not recommended in this population.
Possible side effect
Common adverse reactions include peripheral edema, headache, flushing, and dizziness. Less frequently, patients may experience palpitations, fatigue, nausea, or gingival hyperplasia. Serious side effects, though rare, can include symptomatic hypotension, syncope, or exacerbation of angina. Any persistent or severe side effects should be promptly reported to a healthcare provider.
Drug interaction
Plendil may interact with CYP3A4 inhibitors (e.g., ketoconazole, erythromycin), increasing felodipine levels. Concurrent use with other vasodilators or antihypertensives may potentiate blood pressure-lowering effects. Caution is advised with beta-blockers due to potential additive effects on heart rate and contractility. Grapefruit juice should be avoided as it inhibits CYP3A4 metabolism.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is nearly time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended.
Overdose
Symptoms of overdose may include severe hypotension, bradycardia, and shock. Management involves cardiovascular support, including elevation of extremities and administration of vasopressors if necessary. Since felodipine is highly protein-bound, dialysis is not likely to be beneficial. Gastric lavage may be considered if ingestion was recent.
Storage
Store at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for personalized recommendations, diagnosis, or treatment. Do not initiate, adjust, or discontinue medication without medical supervision.
Reviews
Clinical studies and patient reports generally reflect positive outcomes with Plendil, noting effective blood pressure control and tolerability. Some users report mild peripheral edema, which often resolves with dose adjustment. Physicians appreciate its once-daily dosing and compatibility with other antihypertensive agents.