Prilosec (omeprazole) is a proton pump inhibitor (PPI) designed for the treatment of frequent heartburn and related acid reflux conditions. As a leading over-the-counter and prescription medication, it works by directly reducing stomach acid production at the source. This allows the esophagus to heal and provides long-lasting relief from discomfort, making it a trusted choice among healthcare professionals and patients seeking effective gastrointestinal symptom management.

Features

• Contains omeprazole magnesium as the active ingredient
• Delayed-release tablet formulation for targeted action in the stomach
• Available in 20mg strength for over-the-counter use; prescription strengths also available
• One pill per day dosing for 24-hour heartburn prevention
• Acid-resistant coating to ensure delivery to the intestine for proper absorption

Benefits

• Provides 24-hour relief from frequent heartburn with a single daily dose
• Reduces acid production at the source, allowing damaged esophageal tissue to heal
• Prevents the occurrence of heartburn symptoms rather than merely treating them after they appear
• Can be used as part of a treatment plan for GERD (gastroesophageal reflux disease)
• Available without a prescription for convenient access, while stronger doses remain prescription-only for severe cases
• Supported by extensive clinical research and decades of real-world use

Common use

Prilosec is commonly used for the short-term treatment of frequent heartburn (occurring two or more days per week). It is also used for the management of gastroesophageal reflux disease (GERD), erosive esophagitis, and conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Some healthcare providers may recommend it in combination with antibiotics for the eradication of Helicobacter pylori in peptic ulcer disease.

Dosage and direction

For over-the-counter use: Take one 20mg tablet daily with a glass of water before eating in the morning. Swallow whole; do not crush, chew, or break the tablet. Treatment should be limited to 14 days consecutively, and may be repeated every 4 months if needed. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor.
Prescription dosing varies based on condition being treated, typically ranging from 20mg to 40mg daily, and may be administered once or twice per day as directed by a healthcare provider.

Precautions

• Not intended for immediate relief of heartburn; may take 1 to 4 days for full effect
• Do not use if you have trouble or pain swallowing food, vomiting with blood, or bloody or black stools
• Consult a doctor before use if you have heartburn for over 3 months, frequent chest pain, unexplained weight loss, nausea or vomiting, stomach pain, or if you are taking prescription medications
• Long-term use may be associated with increased risk of bone fractures, low magnesium levels, or vitamin B12 deficiency
• Not recommended for use beyond 14 days without medical supervision

Contraindications

Prilosec is contraindicated in patients with known hypersensitivity to omeprazole or any substituted benzimidazoles. It should not be used by those taking rilpivirine-containing products due to potential for reduced antiviral efficacy. Use is not recommended in patients with suspected gastric malignancy, as symptom relief may delay diagnosis.

Possible side effect

Common side effects may include headache, abdominal pain, diarrhea, nausea, flatulence, vomiting, and constipation. Less frequently, dizziness, rash, cough, or back pain may occur. Serious side effects requiring medical attention include severe diarrhea, kidney problems (urine changes, swelling), low magnesium (dizziness, muscle spasms), or signs of lupus (rash on cheeks/arms that worsens in sun). Long-term use has been associated with increased risk of fractures, vitamin B12 deficiency, and fundic gland polyps.

Drug interaction

Prilosec may interact with several medications including:

• Clopidogrel: may reduce effectiveness
• Methotrexate: may increase methotrexate levels
• St. John’s Wort, rifampin: may reduce omeprazole effectiveness
• Diazepam, warfarin, phenytoin: may increased levels of these drugs
• Digoxin: may increase digoxin absorption
• HIV medications (atazanavir, nelfinavir): may reduce antiviral efficacy
• Iron supplements, ketoconazole: may reduce absorption of these medications

Missed dose

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Overdose

In case of overdose, seek medical help immediately or contact a Poison Control Center. Symptoms of overdose may include confusion, drowsiness, blurred vision, rapid heartbeat, nausea, sweating, flushing, headache, dry mouth, and other effects. Treatment is symptomatic and supportive.

Storage

Store at room temperature (20-25°C or 68-77°F) in a dry place. Keep the bottle tightly closed and protect from moisture. Keep out of reach of children. Do not use if the blister pack is torn or broken.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting any new medication or treatment regimen. Follow all directions on the product packaging and do not use for longer than recommended without medical supervision.

Reviews

“After suffering from nightly heartburn for years, Prilosec has been life-changing. The 24-hour protection means I can eat without constant worry.” - Maria K., verified purchaser

“My gastroenterologist recommended Prilosec for my GERD. Within three days, my symptoms were significantly improved. I appreciate that it’s available OTC for maintenance.” - James T.

“Effective but caused some constipation initially. My doctor recommended increasing fiber and water intake, which helped. Still the best solution for my acid reflux.” - Susan L.