Prometrium: Natural Progesterone Support for Hormonal Balance
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| Product dosage: 200mcg | |||
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Synonyms
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Prometrium is a bioidentical progesterone medication designed to supplement or replace the natural hormone in the body. It is formulated with micronized progesterone in a peanut oil base, enhancing bioavailability and absorption. This prescription medication is widely used in hormone replacement therapy (HRT) and reproductive health, offering a natural alternative to synthetic progestins. Its unique formulation supports a range of therapeutic applications with a favorable safety profile when used as directed under medical supervision.
Features
- Contains 100 mg or 200 mg of micronized progesterone per soft gelatin capsule
- Bioidentical to endogenous progesterone, ensuring physiological compatibility
- Formulated in peanut oil to improve absorption and reduce side effects
- Available in easy-to-swallow oral capsules
- Prescription-only medication requiring healthcare provider oversight
Benefits
- Supports endometrial protection in women using estrogen therapy, reducing the risk of hyperplasia
- Helps regulate menstrual cycles in women with progesterone deficiency or anovulation
- May alleviate symptoms of menopause such as hot flashes and night sweats
- Supports early pregnancy in cases of luteal phase defect or recurrent miscarriage
- Provides a natural hormone option with fewer androgenic effects compared to some synthetic progestins
- Promotes restful sleep for some users due to progesterone’s calming effects
Common use
Prometrium is commonly prescribed as part of hormone replacement therapy for menopausal women with an intact uterus to counteract estrogen’s effects on the endometrium. It is also used to treat secondary amenorrhea and to support luteal phase deficiency in fertility treatments. In some cases, it is utilized off-label for preventing preterm birth, though other formulations may be preferred for this indication. Always use under the guidance of a healthcare professional familiar with your medical history.
Dosage and direction
Dosage varies based on indication. For menopausal HRT: typically 200 mg daily for 12 sequential days per 28-day cycle. For secondary amenorrhea: 400 mg daily at bedtime for 10 days. For luteal phase support: often 200-300 mg daily at bedtime, starting at ovulation and continuing through early pregnancy if applicable. Take with food to improve absorption and minimize dizziness. Swallow capsules whole; do not crush or chew. Follow your prescriber’s instructions precisely regarding timing and duration.
Precautions
Inform your healthcare provider if you have a history of blood clots, stroke, heart disease, liver dysfunction, breast cancer, or depression. Prometrium may cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you. Regular monitoring, including breast exams and pelvic exams, is recommended during long-term use. This medication contains peanut oil; avoid if you have a peanut allergy. Not recommended for use during breastfeeding without medical advice.
Contraindications
Do not use Prometrium if you have known hypersensitivity to progesterone, peanut allergy, or any component of the formulation. Contraindicated in patients with current or history of thrombophlebitis or thromboembolic disorders, undiagnosed abnormal genital bleeding, known or suspected progesterone-sensitive cancers (e.g., breast cancer), missed abortion, or severe liver disease. Not for use during pregnancy except under specific circumstances as directed by a healthcare provider.
Possible side effect
Common side effects may include dizziness, drowsiness, breast tenderness, bloating, mood swings, headache, and breakthrough bleeding. Less frequently, users may experience nausea, diarrhea, fatigue, or rash. Serious but rare side effects include allergic reactions, vision changes, significant depression, jaundice, or signs of blood clots (e.g., sudden leg pain, shortness of breath). Report any persistent or severe symptoms to your healthcare provider promptly.
Drug interaction
Prometrium may interact with drugs that induce liver enzymes, such as carbamazepine, rifampin, or St. John’s wort, potentially reducing its effectiveness. Conversely, it may enhance the effects of other CNS depressants like alcohol, benzodiazepines, or opioids. Use caution with other hormone therapies. Always inform your prescriber of all medications, supplements, and herbal products you are taking to avoid potential interactions.
Missed dose
If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to catch up. If you are on a cyclic regimen, contact your healthcare provider for guidance, as timing is critical for therapeutic efficacy. Consistent use as prescribed is important for optimal results.
Overdose
Overdose may exacerbate side effects such as severe drowsiness, dizziness, or nausea. There is no specific antidote; treatment is supportive. If suspected overdose occurs, seek immediate medical attention or contact a poison control center. Provide details about the amount taken and any symptoms observed.
Storage
Store at room temperature (20-25°C or 68-77°F) in a dry place, away from light and moisture. Keep the container tightly closed and out of reach of children and pets. Do not use after the expiration date printed on the packaging. Proper disposal of unused medication is recommended through a drug take-back program.
Disclaimer
This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting, changing, or stopping any medication. Individual needs and responses may vary based on health status and other factors.
Reviews
Many users report positive experiences with Prometrium, noting improved hormonal balance and reduced menopausal symptoms. Some mention initial drowsiness that often subsides with continued use. A minority report mood changes or bloating. Effectiveness is highly individual; discuss your experience with your provider to optimize therapy.