Voveran: Potent Relief for Inflammation and Pain
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Synonyms | |||
Voveran (diclofenac) is a highly effective nonsteroidal anti-inflammatory drug (NSAID) prescribed for the management of acute and chronic pain, inflammation, and swelling associated with various musculoskeletal and arthritic conditions. As a trusted medication in the NSAID class, it works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins, which are key mediators of pain and inflammation. Available in multiple formulations, including tablets, topical gels, and injections, Voveran offers targeted relief and improved functional outcomes for patients. Its well-established efficacy profile makes it a cornerstone in therapeutic regimens for inflammatory disorders, providing significant symptomatic control and enhancing quality of life.
Features
- Contains diclofenac sodium or diclofenac potassium as the active ingredient
- Available in oral tablets, sustained-release tablets, topical gel, suppositories, and injectable forms
- Rapid onset of action, with pain relief often experienced within 30 minutes to one hour for immediate-release formulations
- Dual inhibition of COX-1 and COX-2 enzymes, providing broad anti-inflammatory and analgesic effects
- Multiple strengths tailored to condition severity and patient needs (e.g., 25 mg, 50 mg, 75 mg, 100 mg tablets; 1% or 2% gel)
- Some formulations designed for once-daily dosing to improve adherence
- Manufactured under strict pharmaceutical quality control standards
Benefits
- Effectively reduces pain and discomfort from conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
- Decreases inflammation and swelling, improving joint mobility and physical function
- Provides rapid relief for acute musculoskeletal injuries, such as sprains and strains
- Helps manage dysmenorrhea (painful menstrual cramps) and other acute pain episodes
- Topical formulation minimizes systemic exposure, reducing risk of gastrointestinal side effects
- Supports long-term management of chronic inflammatory conditions with appropriate monitoring
Common use
Voveran is commonly prescribed for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. It is also indicated for the management of acute pain in adults, such as that associated with dental procedures, postoperative settings, or minor traumatic injuries. Additionally, it is used for the treatment of ankylosing spondylitis, acute gout, and primary dysmenorrhea. The topical gel formulation is specifically approved for the treatment of actinic keratoses and for the relief of pain associated with osteoarthritis in joints amenable to topical treatment, such as the knees and hands.
Dosage and direction
Dosage varies based on the formulation and specific condition being treated. For oral tablets in adults with osteoarthritis: 100-150 mg per day in divided doses (50 mg two or three times daily, or 75 mg twice daily). For rheumatoid arthritis: 150-200 mg per day in divided doses. For acute pain or primary dysmenorrhea: 50 mg three times daily. The maximum recommended daily dose is 150 mg for most conditions. Topical gel (1% or 2%) should be applied four times daily to the affected area; the total dose should not exceed 32 grams per day for the 1% formulation or 16 grams per day for the 2% formulation. Always take with food or milk to minimize gastrointestinal upset. Do not crush, chew, or split sustained-release tablets. Use the lowest effective dose for the shortest duration possible.
Precautions
Use with caution in patients with a history of gastrointestinal bleeding, ulceration, or perforation. Monitor renal function in patients with impaired renal function, heart failure, hepatic dysfunction, those taking diuretics or ACE inhibitors, and the elderly. Avoid use in patients with severe heart failure unless benefits outweigh risks. Caution is advised in patients with hypertension; blood pressure should be monitored closely during treatment. Use topical formulations only on intact skin; avoid contact with eyes, mucous membranes, and open wounds. Do not apply external heat or occlusive dressings over the topical application site. Patients should be advised to avoid alcohol consumption during therapy, as it may increase the risk of gastrointestinal bleeding.
Contraindications
Voveran is contraindicated in patients with known hypersensitivity to diclofenac or any components of the formulation. It should not be used in patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Contraindicated in the setting of coronary artery bypass graft (CABG) surgery. Do not use in patients with active gastrointestinal bleeding or peptic ulcer disease. Avoid use in patients with severe renal impairment or active hepatic disease. Not recommended during the third trimester of pregnancy. Contraindicated in patients with inflammatory bowel disease. Topical formulations are contraindicated on damaged or infected skin.
Possible side effect
Common side effects include nausea, dyspepsia, diarrhea, abdominal pain, and flatulence. Headache, dizziness, and rash may occur. Serious side effects can include gastrointestinal bleeding, ulceration, or perforation; hepatotoxicity (elevated liver enzymes, jaundice); renal impairment; hypertension; heart failure; and severe skin reactions such as exfoliative dermatitis or Stevens-Johnson syndrome. Cardiovascular thrombotic events, including myocardial infarction and stroke, may occur. Topical application may cause local reactions like dryness, itching, redness, or irritation at the site of application.
Drug interaction
Voveran may increase the toxicity of lithium, methotrexate, and cyclosporine by reducing their renal clearance. Concurrent use with other NSAIDs or corticosteroids increases the risk of gastrointestinal adverse effects. It may reduce the antihypertensive effect of ACE inhibitors, angiotensin II receptor blockers, and beta-blockers. Diclofenac may enhance the effects of warfarin and other anticoagulants, increasing the risk of bleeding. Concurrent use with diuretics may lead to reduced natriuretic effect and worsened renal function. Aspirin may decrease diclofenac levels and increase gastrointestinal side effects. Topical diclofenac has minimal systemic absorption, but theoretical interactions with systemic drugs exist.
Missed dose
If a dose is missed, take it as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed one. For topical formulations, apply the next dose at the regular time; do not apply extra gel to compensate. Maintaining a consistent dosing schedule is important for optimal therapeutic effect, but occasional missed doses are unlikely to significantly impact long-term management.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, and apnea. Hypertension, acute renal failure, and respiratory depression are possible in severe cases. There is no specific antidote. Management is supportive and symptomatic. Gastric lavage or activated charcoal may be considered if presented soon after ingestion. Forced diuresis, hemodialysis, or hemoperfusion are unlikely to be beneficial due to high protein binding. Monitor and support vital functions, especially renal and hepatic parameters.
Storage
Store at room temperature (15-30°C or 59-86°F) in a dry place, protected from light and moisture. Keep oral formulations in their original container, tightly closed. Topical gel should be stored at room temperature; avoid freezing. Keep all medications out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused or expired medication according to local guidelines, preferably through a medicine take-back program.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Do not disregard professional medical advice or delay in seeking it because of something you have read here. The use of Voveran should be under the supervision of a healthcare professional, and individual patient needs may vary.
Reviews
Clinical studies and patient reports consistently affirm Voveran’s efficacy in managing inflammatory pain and improving joint function. Many patients with osteoarthritis and rheumatoid arthritis experience significant relief, noting reduced stiffness and enhanced mobility. The topical formulation is particularly praised for its localized effect with minimal systemic side effects. However, some users report gastrointestinal discomfort with oral forms, emphasizing the importance of taking it with food. Overall, it remains a widely trusted option in NSAID therapy when used appropriately under medical guidance.