Wellbutrin SR (bupropion hydrochloride sustained-release) is a prescription antidepressant medication belonging to the aminoketone class, distinct from commonly prescribed SSRIs. It is specifically formulated to help manage symptoms of major depressive disorder (MDD) in adults through a sustained-release mechanism that maintains consistent plasma levels. Its unique neurochemical profile targets norepinephrine and dopamine reuptake inhibition, offering a valuable alternative for patients who may not tolerate or respond adequately to serotonergic agents. Clinical evidence supports its efficacy in improving mood, energy, and focus while minimizing certain side effects associated with other antidepressants.

Features

• Active ingredient: Bupropion hydrochloride (150 mg per tablet)
• Formulation: Sustained-release oral tablets
• Pharmacologic class: Aminoketone antidepressant, norepinephrine-dopamine reuptake inhibitor (NDRI)
• Administration: Oral, twice daily
• Available in blister packs of 60 tablets

Benefits

• Helps alleviate symptoms of depression such as low mood, loss of interest, and fatigue
• May improve concentration and motivation with minimal impact on sexual function
• Lower risk of weight gain compared to some other antidepressants
• Does not typically cause sedation, supporting daytime alertness
• Sustained-release design provides steady drug levels for consistent symptom control

Common use

Wellbutrin SR is indicated for the treatment of major depressive disorder (MDD) in adults. It may also be used off-label for seasonal affective disorder (SAD) and as an aid to smoking cessation, though the SR formulation is not FDA-approved for the latter indication. It is often selected for patients who experience undesirable effects such as sexual dysfunction or weight gain with SSRIs or SNRIs.

Dosage and direction

The recommended starting dose for Wellbutrin SR is 150 mg once daily in the morning. After at least 3 days, the dose may be increased to 150 mg twice daily, with at least 8 hours between doses. The maximum recommended dose is 400 mg per day, given as 200 mg twice daily. Tablets should be swallowed whole and not crushed, chewed, or divided, to maintain the sustained-release properties. Dosage adjustments should be guided by a healthcare provider based on clinical response and tolerability.

Precautions

Patients should be monitored for worsening depression, suicidality, or unusual changes in behavior, especially at the beginning of treatment or during dosage adjustments. Wellbutrin SR may lower the seizure threshold; use with caution in patients with a history of seizure disorder, head trauma, or concomitant medications that may increase seizure risk. It may also increase blood pressure; regular monitoring is advised. Use in patients with hepatic or renal impairment requires dosage adjustment and close supervision. Avoid alcohol consumption during treatment.

Contraindications

Wellbutrin SR is contraindicated in patients with a seizure disorder or history of epilepsy. It must not be used in individuals with a current or prior diagnosis of bulimia or anorexia nervosa due to increased seizure risk. Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated; a 14-day washout period is required before initiating Wellbutrin SR. Hypersensitivity to bupropion or any component of the formulation is also a contraindication.

Possible side effects

Common side effects may include dry mouth, nausea, headache, insomnia, and dizziness. Less frequently, patients may experience tremors, sweating, tinnitus, or blurred vision. Serious but rare adverse effects include seizures, hypertension, allergic reactions, and angle-closure glaucoma. Any unusual mood or behavioral changes should be reported immediately to a healthcare provider.

Drug interaction

Wellbutrin SR may interact with drugs that lower the seizure threshold (e.g., antipsychotics, antidepressants, systemic corticosteroids). It can inhibit CYP2D6 enzymes, potentially increasing levels of drugs such as beta-blockers, antipsychotics, and some antidepressants. Concomitant use with other dopaminergic or noradrenergic agents may increase the risk of adverse effects. MAOIs are absolutely contraindicated. Always inform your prescriber of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Maintaining a consistent dosing schedule is important for therapeutic efficacy.

Overdose

Overdose of Wellbutrin SR may lead to seizures, hallucinations, tachycardia, or loss of consciousness. In case of suspected overdose, seek emergency medical attention immediately. Management may include supportive care and monitoring of vital signs; activated charcoal may be considered if ingestion was recent.

Storage

Store at room temperature (20–25°C or 68–77°F) in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and personalized guidance regarding Wellbutrin SR or any medical condition.

Reviews

Clinical studies and patient reports indicate that Wellbutrin SR is often well-tolerated and effective for improving depressive symptoms, particularly in individuals concerned about weight gain or sexual side effects. Some users note initial side effects such as restlessness or insomnia, which often subside with continued use. Outcomes vary by individual; discuss your experience with your prescriber to optimize treatment.