Zestoretic: Advanced Dual-Action Hypertension Control
| Product dosage: 17.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.48 | $44.26 (0%) | 🛒 Add to cart |
| 60 | $1.17 | $88.52 $70.42 (20%) | 🛒 Add to cart |
| 90 | $1.07 | $132.78 $96.57 (27%) | 🛒 Add to cart |
| 120 | $1.01 | $177.05 $121.72 (31%) | 🛒 Add to cart |
| 180 | $0.96 | $265.57 $173.02 (35%) | 🛒 Add to cart |
| 270 | $0.93 | $398.35 $250.48 (37%) | 🛒 Add to cart |
| 360 | $0.91
Best per pill | $531.14 $327.94 (38%) | 🛒 Add to cart |
Synonyms | |||
Zestoretic is a prescription medication combining two powerful antihypertensive agents, lisinopril and hydrochlorothiazide, into a single tablet. It is specifically formulated for patients whose blood pressure is not adequately controlled by monotherapy. This combination offers a synergistic effect, targeting multiple pathways of blood pressure regulation for superior management of hypertension and a reduced pill burden, thereby supporting long-term adherence to treatment regimens.
Features
- Contains lisinopril, an angiotensin-converting enzyme (ACE) inhibitor
- Contains hydrochlorothiazide, a thiazide diuretic
- Available in multiple strength combinations (e.g., lisinopril 10 mg / hydrochlorothiazide 12.5 mg, lisinopril 20 mg / hydrochlorothiazide 12.5 mg, etc.)
- Oral tablet formulation for once-daily administration
- Typically prescribed when monotherapy provides insufficient blood pressure reduction
Benefits
- Provides superior blood pressure lowering compared to either component alone
- Reduces the risk of major cardiovascular events associated with uncontrolled hypertension
- Simplifies treatment regimen, improving patient compliance
- Addresses fluid retention through diuretic action while modulating the renin-angiotensin-aldosterone system
- May be cost-effective compared to purchasing two separate medications
- Supports long-term cardiovascular health management
Common use
Zestoretic is indicated for the treatment of hypertension in patients for whom combination therapy is appropriate. It is not indicated for initial therapy. It is commonly prescribed for patients who have shown an inadequate response to lisinopril or hydrochlorothiazide alone, or for those whose blood pressure requires control through multiple mechanisms. It is also utilized in the management of certain cases of heart failure, though this is off-label and requires careful medical supervision.
Dosage and direction
The dosage of Zestoretic must be individualized based on the patient’s previous antihypertensive therapy and blood pressure response. The usual recommended starting dose is one tablet of Zestoretic 10/12.5 (lisinopril 10 mg and hydrochlorothiazide 12.5 mg) once daily. Dosage may be titrated upward as necessary, typically at intervals of 2 to 3 weeks. The maximum recommended daily dose is lisinopril 80 mg and hydrochlorothiazide 50 mg. It should be taken orally, with or without food, preferably at the same time each day to maintain consistent blood levels. Dose adjustment is necessary in patients with renal impairment.
Precautions
Patients should be monitored for hypotension, especially after the initial dose or following dosage increases. Renal function and serum electrolytes, particularly potassium, sodium, and creatinine, should be assessed prior to initiation and periodically during therapy. Use with caution in patients with impaired renal function, hepatic disease, or pre-existing electrolyte imbalances. Avoid use in patients with history of angioedema. Caution is advised in patients undergoing surgery or anesthesia. Patients should be advised to avoid dehydration and excessive perspiration. Photosensitivity reactions may occur.
Contraindications
Zestoretic is contraindicated in patients with a history of hypersensitivity to any ACE inhibitor, any sulfonamide-derived drugs, or any component of this formulation. It is contraindicated in patients with anuria. Do not co-administer with aliskiren in patients with diabetes. Contraindicated in pregnancy due to potential for fetal harm. Avoid use in patients with hereditary or idiopathic angioedema.
Possible side effect
Common side effects may include dizziness, headache, cough, fatigue, and orthostatic hypotension. Gastrointestinal effects such as nausea or diarrhea may occur. Potential serious side effects include angioedema, hyperkalemia, hyponatremia, hypokalemia, renal impairment, pancreatitis, and photosensitivity reactions. Less common but serious adverse effects may include neutropenia/agranulocytosis, hepatic failure, and systemic lupus erythematosus. Patients should report any signs of infection, jaundice, or unexplained bruising/bleeding.
Drug interaction
Concomitant use with other antihypertensive agents may potentiate blood pressure lowering effects. NSAIDs may reduce the antihypertensive effect and increase risk of renal impairment. Potassium-sparing diuretics or potassium supplements may increase risk of hyperkalemia. Lithium levels may increase. Use with caution with insulin or oral hypoglycemics as hydrochlorothiazide may decrease glucose tolerance. Alcohol, barbiturates, or narcotics may potentiate orthostatic hypotension. Diabetic therapy may require adjustment.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Do not double the dose to make up for a missed one. Patients should be advised to maintain consistency in dosing to ensure optimal blood pressure control.
Overdose
Symptoms of overdose may include severe hypotension, electrolyte imbalances, dehydration, and renal failure. Bradycardia may occur. Management involves supportive measures including intravenous fluids for volume expansion and vasopressors if necessary. Lisinopril may be removed by dialysis. Serum electrolytes and creatinine should be monitored closely. Gastric lavage may be considered if ingestion was recent. Specific treatment should be directed at correcting hypotension and electrolyte abnormalities.
Storage
Store at controlled room temperature between 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C to 30°C (59°F to 86°F). Keep in the original container with the lid tightly closed to protect from moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Protect from excessive light and humidity.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Zestoretic is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Patients should not initiate, discontinue, or change dosage without consulting their physician. The prescribing information provided here may not be comprehensive; please refer to the official prescribing information for complete details.
Reviews
Clinical studies have demonstrated the efficacy of Zestoretic in significantly reducing both systolic and diastolic blood pressure compared to monotherapy components. Many patients report improved quality of life due to better blood pressure control and simplified dosing regimen. Some patients note the convenience of combination therapy, though others report experiencing side effects such as persistent cough or dizziness. Healthcare providers generally regard it as an effective option for appropriate patients who require combination antihypertensive therapy. Long-term adherence rates appear favorable compared to free combinations of the individual components.