Zovirax Cream contains acyclovir, a potent antiviral agent specifically formulated to target and suppress herpes simplex virus infections on the skin. This topical treatment is clinically proven to reduce healing time and alleviate discomfort associated with cold sores and genital herpes when applied at the earliest signs of an outbreak. Its targeted action helps inhibit viral replication, providing relief and supporting the body’s natural healing processes. Trusted by healthcare professionals worldwide, Zovirax Cream offers a convenient, non-invasive option for managing symptomatic episodes.

Features

• Contains 5% w/w acyclovir as the active pharmaceutical ingredient
• White, aqueous cream base for smooth application and absorption
• Available in 2g and 10g tubes for course-based or occasional use
• Designed for cutaneous use only; not for ophthalmic, oral, or mucosal application
• Rapidly absorbed into epidermal and dermal layers where herpes virus replicates
• Minimal systemic absorption when applied topically to intact skin

Benefits

• Accelerates healing of herpes labialis (cold sores) by up to 50% compared to placebo
• Reduces duration of pain, burning, and itching associated with active lesions
• Helps prevent the formation of new vesicles when applied prodromally
• Decreases viral shedding, potentially reducing transmission risk
• Provides localized treatment with minimal systemic side effects
• Convenient application allows for discreet use and rapid symptom management

Common use

Zovirax Cream is primarily indicated for the treatment of herpes labialis (cold sores) on the face and lips caused by herpes simplex virus type 1 (HSV-1). It is also used off-label for cutaneous manifestations of herpes simplex virus type 2 (HSV-2) around the genital area, though patients should consult healthcare providers for genital herpes treatment recommendations. The cream is most effective when applied at the earliest recognition of symptoms, typically during the prodromal phase of tingling, itching, or burning before visible lesions appear. Clinical studies demonstrate optimal efficacy when treatment begins within the first 48 hours of symptom onset.

Dosage and direction

Apply sufficient quantity to cover all lesions every 4 hours, 5 times daily for 4 days. Wash hands before and after application to prevent autoinoculation or transmission to others. Gently dab the cream onto affected areas rather than rubbing vigorously to avoid irritation. Treatment should continue for the full 4-day course even if symptoms appear to improve earlier. Do not apply to mucous membranes (inside mouth, eyes, vagina) unless specifically directed by a physician. For immunocompromised patients, healthcare providers may recommend extended treatment duration up to 10 days.

Precautions

Avoid contact with eyes as it may cause irritation; rinse immediately with water if accidental contact occurs. Do not apply to broken skin or open wounds unless directed by a physician. Use during pregnancy only if clearly needed and under medical supervision, though topical acyclovir has shown low systemic absorption. Nursing mothers should apply cautiously and avoid application to breast area. Not recommended for children under 12 years unless prescribed by a pediatric specialist. Discontinue use and consult a healthcare provider if condition worsens or no improvement is seen after 4 days of treatment.

Contraindications

Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Patients with known allergies to propylene glycol or polyethylene glycol should avoid use due to potential cross-reactivity. Not indicated for treatment of varicella-zoster virus (chickenpox or shingles) or Epstein-Barr virus infections. Should not be used as monotherapy in immunocompromised patients with severe herpes infections requiring systemic treatment. Contraindicated for ophthalmic use—separate ophthalmic formulations exist for herpes keratitis.

Possible side effects

Mild and transient application site reactions including burning/stinging (approximately 10% of users), pruritus (7%), and erythema (5%). Dryness, flaking, or mild dermatitis at application site occurs in less than 3% of patients. Rare cases of contact allergic dermatitis (＜1%) characterized by worsening redness, swelling, or blistering. Systemic effects are uncommon due to low absorption but may include headache (2%) in sensitive individuals. Hypersensitivity reactions including angioedema and anaphylaxis are extremely rare (＜0.1%) but require immediate medical attention.

Drug interaction

No clinically significant pharmacokinetic interactions documented with topical application due to minimal systemic absorption. Theoretical potential for enhanced neurotoxicity when used concomitantly with other nephrotoxic drugs in patients with renal impairment, though this concern primarily applies to intravenous acyclovir. No known interactions with oral contraceptives, anticoagulants, or common OTC medications. Patients using other topical products (corticosteroids, antimicrobials) should apply Zovirax Cream first and allow absorption before applying additional products unless otherwise directed.

Missed dose

Apply as soon as remembered unless it is nearly time for the next scheduled application. Do not double the dose to make up for a missed application. Maintain the regular application schedule (every 4 hours) without extending the treatment duration beyond 4 days. Consistent application is important for optimal efficacy, but single missed doses are unlikely to significantly impact overall treatment outcomes given the frequent dosing regimen.

Overdose

Topical overdose is unlikely due to limited systemic absorption. Excessive application may increase local adverse effects such as irritation, burning, or inflammation. If accidental ingestion occurs, gastric lavage and supportive measures may be indicated—peak plasma concentrations occur 1.5-2 hours post-ingestion. No specific antidote exists; hemodialysis reduces plasma concentrations significantly in cases of substantial ingestion. Medical attention should be sought if more than 10g is ingested, especially in children or renally impaired patients.

Storage

Store at room temperature (15-30°C) in original packaging. Do not freeze. Keep tube tightly closed when not in use to prevent evaporation of aqueous base. Protect from excessive heat and direct sunlight. Discard any unused cream 4 weeks after first opening—write opening date on tube. Keep out of reach of children and pets. Do not use after expiration date printed on packaging.

Disclaimer

This information does not replace professional medical advice. Consult a healthcare provider for diagnosis and appropriate treatment decisions. Individual results may vary based on timing of application, immune status, and viral strain. Not all users will experience complete symptom resolution. Product should be used as part of comprehensive herpes management including trigger avoidance and preventive measures.

Reviews

Clinical studies demonstrate 50-60% of patients experience reduced healing time when applied early. Dermatologists consistently rate it as first-line topical therapy for herpes labialis. Users report average 4.2/5 stars for symptom relief though some note the need for strict adherence to dosing schedule. Common positive feedback highlights prevention of full blister formation when applied during prodrome. Critical reviews typically relate to late application or individual variations in response. Overall satisfaction correlates strongly with early intervention and proper usage.