Benoquin Cream is a topical medical treatment containing monobenzone as its active ingredient, designed for the permanent depigmentation of remaining pigmented skin in extensive vitiligo. It is prescribed when repigmentation is no longer feasible or desired, offering a uniform skin tone. This cream works by irreversibly inhibiting melanocyte function, leading to gradual lightening of the skin. Use under strict dermatological supervision is essential to ensure safety and desired outcomes.

Features

• Active ingredient: Monobenzone 200 mg/g (20% w/w)
• Topical formulation for targeted application
• Requires prescription-only access
• Designed for gradual, permanent depigmentation
• Suitable for use on extensive unaffected skin areas in vitiligo patients

Benefits

• Achieves a more uniform skin appearance in cases of widespread vitiligo
• Reduces the visual contrast between pigmented and depigmented regions
• May improve quality of life by minimizing the noticeable effects of the condition
• Provides a controlled and medical approach to skin depigmentation
• Can be applied precisely to affected areas as directed

Common use

Benoquin Cream is primarily indicated for the permanent depigmentation of normally pigmented skin in patients with extensive, widespread vitiligo (generally involving more than 50% of the body surface area) where repigmentation therapy is not successful or desired. It is not intended for partial or cosmetic use on small areas and should never be used by individuals without vitiligo.

Dosage and direction

Apply a thin layer of Benoquin Cream to the remaining pigmented areas twice daily, or as directed by a healthcare professional. Gently rub into the skin until absorbed. Avoid application near the eyes, mucous membranes, open wounds, or inflamed skin. Treatment response is gradual; depigmentation may take several months. Do not exceed recommended frequency or amount.

Precautions

• For external use only.
• Avoid sun exposure; use broad-spectrum sunscreen on treated areas as depigmented skin is highly susceptible to burning.
• Do not use on children unless specifically advised by a dermatologist.
• Discontinue use if severe irritation, hypersensitivity, or unexpected darkening occurs.
• Wash hands thoroughly after application to prevent accidental transfer.
• Regular monitoring by a dermatologist is mandatory throughout treatment.

Contraindications

Benoquin Cream is contraindicated in patients with a known hypersensitivity to monobenzone or any component of the formulation. It should not be used in patients without vitiligo, or in those with localized or limited vitiligo. Avoid use during pregnancy or breastfeeding unless potential benefits outweigh risks. Do not apply to broken, abraded, or inflamed skin.

Possible side effects

Common side effects may include mild skin irritation, redness, dryness, or itching at the application site. Less frequently, patients may experience dermatitis, burning sensation, or swelling. Rare but serious side effects include paradoxical hyperpigmentation, severe allergic reactions (e.g., rash, hives, difficulty breathing), or depigmentation at distant sites due to accidental transfer. Consult a physician if any adverse effects persist or worsen.

Drug interaction

No specific drug interactions are well-documented with topical monobenzone. However, caution is advised when using other topical medications, cosmetics, or skincare products concurrently, as they may increase irritation or alter absorption. Inform your healthcare provider of all products you are using on your skin.

Missed dose

If a dose is missed, apply it as soon as remembered, unless it is almost time for the next scheduled application. Do not double the dose to make up for a missed one. Maintain the regular application schedule as prescribed.

Overdose

Overapplication or accidental ingestion may lead to intensified local skin reactions or systemic effects such as nausea or dizziness. In case of suspected overdose, wash the affected area thoroughly and seek medical attention immediately. Provide the product packaging to healthcare professionals.

Storage

Store at room temperature (15–30°C), in a dry place away from direct light and heat. Keep the tube tightly closed. Do not freeze. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment recommendations, and personalized guidance. Use strictly as prescribed. The manufacturer is not liable for misuse or incorrect application.

Reviews

Clinical studies and patient reports indicate that Benoquin Cream can be effective in achieving depigmentation in extensive vitiligo when used correctly under supervision. Some users note gradual lightening over 3–6 months, though results vary. Dermatologists emphasize the importance of adherence to safety guidelines to minimize side effects. Patient satisfaction often relates to achieving a more uniform skin tone in widespread cases.