Cefadroxil is a first-generation cephalosporin antibiotic prescribed for the treatment of a wide range of bacterial infections. It functions by inhibiting bacterial cell wall synthesis, leading to the eradication of susceptible microorganisms. This medication is valued for its broad-spectrum activity and convenient once- or twice-daily dosing, which supports patient adherence and therapeutic success. Cefadroxil is particularly effective against common pathogens responsible for skin, urinary tract, and upper respiratory infections.

Features

• Belongs to the first-generation cephalosporin class of antibiotics
• Available in oral formulations including capsules, tablets, and powder for suspension
• Bactericidal action through inhibition of cell wall synthesis
• Stable in the presence of certain beta-lactamases
• Demonstrated efficacy against Gram-positive and some Gram-negative bacteria
• Typically dosed once or twice daily due to prolonged half-life

Benefits

• Effectively treats common bacterial infections, reducing symptom duration and severity
• Convenient dosing schedule improves compliance, especially in outpatient settings
• Broad-spectrum coverage targets frequently encountered pathogens in community-acquired infections
• Well-established safety profile with extensive clinical use history
• Available in multiple formulations to suit different patient populations, including pediatric patients

Common use

Cefadroxil is commonly prescribed for bacterial infections such as pharyngitis, tonsillitis, skin and soft tissue infections, and uncomplicated urinary tract infections. It is also used for prophylaxis in certain surgical procedures and off-label for other infections where susceptible organisms are identified through culture and sensitivity testing.

Dosage and direction

The typical adult dosage is 1-2 grams per day, administered either as a single dose or divided into two doses. For pediatric patients, the dosage is weight-based, generally 30 mg/kg/day in divided doses. Dosage adjustments are necessary in patients with renal impairment. The medication should be taken with food to minimize gastrointestinal upset, and the full prescribed course must be completed even if symptoms improve earlier.

Precautions

Patients should inform their healthcare provider of any history of gastrointestinal disease, particularly colitis. Use with caution in patients with renal impairment; dosage adjustment is required. Prolonged use may result in fungal or bacterial superinfection. Cefadroxil should be used during pregnancy only if clearly needed and with caution in nursing mothers.

Contraindications

Cefadroxil is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics or any component of the formulation. Cross-sensitivity with penicillins may occur; caution is advised in patients with penicillin allergy.

Possible side effect

Common adverse reactions include diarrhea, nausea, vomiting, and abdominal pain. Less frequently, rash, urticaria, and pruritus may occur. Rare but serious side effects include pseudomembranous colitis, Stevens-Johnson syndrome, and anaphylaxis. Transient elevations in liver enzymes have been reported.

Drug interaction

Probenecid may decrease renal excretion of cefadroxil, increasing serum concentrations. Concurrent use with nephrotoxic drugs may enhance renal adverse effects. Cefadroxil may reduce the efficacy of oral contraceptives; alternative contraceptive methods are recommended during therapy.

Missed dose

If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. In that case, skip the missed dose and resume the regular schedule. Doubling doses is not recommended.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is supportive; hemodialysis may enhance elimination. There is no specific antidote.

Storage

Store at room temperature (15-30°C) in a tight, light-resistant container. Keep suspension refrigerated and discard any unused portion after 14 days. Keep out of reach of children.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for diagnosis and treatment of medical conditions. Do not self-medicate or alter dosages without professional guidance.

Reviews

Clinical studies and post-marketing surveillance demonstrate cefadroxil’s efficacy and tolerability. Healthcare professionals report satisfactory outcomes in treating susceptible infections, with particular appreciation for its convenient dosing regimen. Patient feedback generally indicates good tolerance, though gastrointestinal side effects are noted in some cases.