Celexa (citalopram hydrobromide) is a selective serotonin reuptake inhibitor (SSRI) approved by the FDA for the treatment of major depressive disorder (MDD) in adults. As a well-established antidepressant, it works by increasing serotonin levels in the brain, which helps improve mood, sleep, appetite, and energy levels. Its efficacy, tolerability, and once-daily dosing make it a preferred choice for initiating pharmacotherapy in patients with depression.

Features

• Active ingredient: citalopram hydrobromide
• Available in 10 mg, 20 mg, and 40 mg film-coated tablets
• Once-daily oral administration, with or without food
• FDA-approved for major depressive disorder (MDD)
• Generic versions available for cost-effective treatment

Benefits

• Effectively alleviates symptoms of depression, including low mood and loss of interest
• Helps restore normal sleep patterns and improve energy levels
• Reduces anxiety often associated with depressive disorders
• Generally well-tolerated with a lower incidence of certain side effects compared to older antidepressants
• Supports long-term maintenance therapy to prevent relapse

Common use

Celexa is primarily indicated for the treatment of major depressive disorder (MDD) in adults. It may also be used off-label for other conditions such as generalized anxiety disorder (GAD), panic disorder, and obsessive-compulsive disorder (OCD), though such use should be carefully evaluated and monitored by a healthcare provider.

Dosage and direction

The recommended starting dosage for Celexa is 20 mg once daily, with or without food. Depending on individual patient response and tolerability, the dosage may be increased to a maximum of 40 mg per day. Dosage adjustments should be made at intervals of no less than one week. It is important to follow the prescribing physician’s instructions and not to alter the dose without consultation. Abrupt discontinuation should be avoided; instead, gradual tapering is recommended under medical supervision.

Precautions

Patients should be monitored for clinical worsening, suicidality, or unusual changes in behavior, especially at the beginning of treatment or during dosage adjustments. Celexa may cause hyponatremia or abnormal bleeding; caution is advised in elderly patients or those taking concomitant medications that affect sodium levels or coagulation. Use with care in patients with a history of mania, seizures, or hepatic impairment. Celexa is not approved for use in pediatric patients.

Contraindications

Celexa is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy due to the risk of serotonin syndrome. It is also contraindicated in individuals with known hypersensitivity to citalopram or any component of the formulation, and in those with congenital long QT syndrome or certain cardiac conditions.

Possible side effect

Common side effects may include nausea, dry mouth, increased sweating, sleepiness, insomnia, and fatigue. Sexual dysfunction, such as decreased libido or delayed ejaculation, may occur. Less frequently, patients may experience QT prolongation, serotonin syndrome, or discontinuation symptoms. Most side effects are mild to moderate and often diminish with continued use.

Drug interaction

Celexa has the potential to interact with other serotonergic drugs (e.g., other SSRIs, SNRIs, triptans), which may increase the risk of serotonin syndrome. It may also interact with drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics. Concomitant use with NSAIDs or anticoagulants may elevate bleeding risk. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose is missed, it should be taken as soon as remembered, unless it is close to the time of the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include dizziness, sweating, nausea, vomiting, tremor, and in severe cases, seizures or ECG changes. Serotonin syndrome is also a risk. In case of suspected overdose, seek immediate medical attention or contact a poison control center.

Storage

Store Celexa tablets at room temperature (15–30°C or 59–86°F) in a tightly closed container, away from light and moisture. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting or changing any medication regimen.

Reviews

Clinical studies and patient reports generally reflect positive experiences with Celexa, noting its effectiveness in managing depressive symptoms with a favorable side effect profile for many individuals. Some users report initial side effects such as nausea or drowsiness, which often subside over time. As with any antidepressant, individual responses can vary.