Ciloxan (ciprofloxacin hydrochloride ophthalmic solution) 0.3% is a sterile, antimicrobial topical solution formulated for the treatment of ocular infections caused by susceptible strains of microorganisms. As a fluoroquinolone antibiotic, it offers potent bactericidal activity against a broad spectrum of gram-positive and gram-negative bacteria. This prescription medication is indicated for corneal ulcers and bacterial conjunctivitis, providing targeted therapy directly at the site of infection. Its optimized formulation ensures stability and consistent delivery of the active ingredient.

Features

• Contains 0.3% ciprofloxacin hydrochloride as the active ingredient
• Sterile, isotonic, buffered solution with pH approximately 4.5
• Preservative: benzalkonium chloride 0.006%
• Available in 2.5 mL and 5 mL sterile dropper bottles
• Bactericidal action through inhibition of bacterial DNA gyrase and topoisomerase IV

Benefits

• Rapidly achieves bactericidal concentrations in ocular tissues
• Broad-spectrum coverage against common ocular pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
• Reduces signs and symptoms of bacterial conjunctivitis within days of initiation
• Promotes healing of corneal ulcers while minimizing risk of perforation
• Convenient dosing regimen enhances patient compliance
• Minimal systemic absorption when used as directed

Common use

Ciloxan ophthalmic solution is primarily prescribed for the treatment of bacterial conjunctivitis caused by susceptible strains of organisms. It is also indicated for corneal ulcers caused by susceptible strains of bacteria. Healthcare providers may consider its use for perioperative prophylaxis in ocular surgery and for managing other external ocular infections when susceptibility is confirmed. The solution is appropriate for both adult and pediatric patients (1 year and older).

Dosage and direction

For bacterial conjunctivitis: Instill 1-2 drops into the affected eye(s) every 2 hours while awake for the first 2 days, then 1-2 drops every 4 hours while awake for the next 5 days.

For corneal ulcers: Instill 2 drops into the affected eye every 15 minutes for the first 6 hours, then 2 drops every 30 minutes for the remainder of the first day. On day 2, instill 2 drops hourly while awake. On days 3 through 14, instill 2 drops every 4 hours while awake.

Wash hands before use. Avoid touching dropper tip to any surface to prevent contamination. Do not wear contact lenses during treatment.

Precautions

• Use under medical supervision only; complete full course of treatment
• Not for injection or oral use; for ophthalmic use only
• May cause temporary blurred vision after instillation; avoid driving or operating machinery until vision clears
• Fungal superinfection may occur with prolonged use
• Use with caution in patients with history of hypersensitivity to quinolones
• Remove contact lenses before application; may be reinserted after 15 minutes
• Discontinue use and consult physician if symptoms persist or worsen after 7 days

Contraindications

• History of hypersensitivity to ciprofloxacin, other quinolones, or any component of the formulation
• Viral keratitis or conjunctivitis (herpes simplex, varicella)
• Fungal ocular infections
• Non-bacterial ocular inflammations

Possible side effect

Most common: transient ocular burning, discomfort, or itching immediately after instillation; blurred vision; foreign body sensation; photophobia; unpleasant taste following nasolacrimal duct drainage.

Less common: corneal staining; conjunctival hyperemia; tearing; dryness; lid margin crusting; ocular edema; nausea; decreased vision; corneal infiltrates.

Rare: allergic reactions including rash, urticaria, itching, angioedema; anaphylaxis; crystalline deposits in superficial portion of corneal defect; lid edema; conjunctival hemorrhage.

Drug interaction

No formal drug interaction studies have been conducted with ophthalmic ciprofloxacin. However, systemic quinolones interact with: theophylline (increased theophylline levels), warfarin (potentiated anticoagulant effect), cyclosporine (elevated serum creatinine), and antacids containing magnesium, aluminum, or calcium (reduced absorption). While systemic absorption is minimal with ophthalmic use, caution is advised when using concurrently with these medications.

Missed dose

Apply the missed dose as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. Maintain approximate dosing intervals to ensure consistent therapeutic levels.

Overdose

Ocular overdose may be flushed from the eye(s) with warm tap water. Symptoms of excessive topical application might include increased ocular irritation, conjunctival hyperemia, or corneal changes. Systemic absorption following ocular administration is minimal, making systemic overdose unlikely. If accidentally ingested, seek medical attention promptly as systemic ciprofloxacin overdose may cause nausea, vomiting, diarrhea, headache, dizziness, and seizures.

Storage

Store at controlled room temperature 15°-30°C (59°-86°F). Protect from light. Keep bottle tightly closed when not in use. Do not freeze. Discard any unused solution 4 weeks after opening. Keep out of reach of children. Do not use if solution changes color or becomes cloudy.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment recommendations. Individual response to medication may vary. The prescribing physician should be informed of all current medications and medical conditions before using this product.

Reviews

Clinical studies demonstrate Ciloxan’s efficacy with 85-92% of patients with bacterial conjunctivitis showing clinical resolution after 7 days of treatment. For corneal ulcers, 80% of patients achieved complete re-epithelialization within 14 days. Ophthalmologists report good tolerability profile with most adverse effects being mild and transient. Patients appreciate the convenient dosing schedule and rapid symptom relief, though some note temporary stinging upon application.