Lquin is a potent fluoroquinolone antibiotic medication designed to combat a wide spectrum of serious bacterial infections. With its targeted bactericidal action, Lquin effectively eliminates pathogenic bacteria by inhibiting DNA gyrase and topoisomerase IV, crucial enzymes for bacterial replication. This makes it a frontline choice for healthcare providers treating complex infections where other antibiotics may fail. Available in both oral and intravenous formulations, Lquin ensures flexible administration tailored to patient needs and clinical severity.

Features

• Active ingredient: Levofloxacin
• Available in 250mg, 500mg, and 750mg tablets
• IV infusion solution: 25mg/mL in single-use vials
• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Rapid absorption with high bioavailability (~99%)
• Half-life of approximately 6–8 hours allowing for once or twice daily dosing

Benefits

• Effectively treats respiratory, urinary tract, skin, and abdominal infections
• Reduces risk of complication progression through rapid bactericidal action
• Convenient dosing schedule improves patient adherence
• Suitable for both community-acquired and hospital-acquired infections
• Demonstrates reliable tissue penetration, including lung and prostate
• May be used as step-down therapy following IV treatment

Common use

Lquin is commonly prescribed for adults with bacterial pneumonia, acute bacterial sinusitis, chronic bronchitis exacerbations, complicated urinary tract infections, and skin structure infections. It is also indicated for prophylaxis and treatment of inhalation anthrax and plague. Off-label uses may include certain sexually transmitted infections and prosthetic joint infections, though these require specialist oversight.

Dosage and direction

The standard dosage for most infections is 500mg orally or intravenously once daily for 7–14 days. For severe or complicated infections, 750mg once daily may be prescribed. Renal function must be assessed before initiation; dosage adjustment is required for patients with creatinine clearance below 50mL/min. Tablets should be taken with a full glass of water, with or without food, though administration one hour before or two hours after meals may optimize absorption. IV infusion should be administered over 60–90 minutes to minimize vein irritation.

Precautions

Patients should maintain adequate hydration to prevent crystal formation in urine. Avoid prolonged sun exposure and use sunscreen due to photosensitivity risk. Caution is advised in elderly patients due to potential tendonitis and tendon rupture risk. Regular monitoring of renal and hepatic function is recommended during extended therapy. Discontinue immediately if symptoms of peripheral neuropathy occur.

Contraindications

Lquin is contraindicated in patients with known hypersensitivity to levofloxacin or other quinolones. Should not be used in patients with history of tendon disorders related to fluoroquinolone use. Not recommended for children, adolescents, pregnant women, or nursing mothers due to risk of arthropathy. Avoid in patients with epilepsy or predisposition to seizures.

Possible side effect

Common side effects include nausea (3–5%), diarrhea (2–4%), headache (2–3%), and insomnia (1–2%). Less frequently, patients may experience dizziness, abdominal pain, or photosensitivity reactions. Serious adverse effects include tendon inflammation or rupture (0.1–0.4%), peripheral neuropathy, CNS effects including seizures, and QT interval prolongation. Pseudomembranous colitis has been reported with all antibacterial agents.

Drug interaction

Concomitant use with corticosteroids increases tendon rupture risk. Antacids containing magnesium, aluminum, or calcium; sucralfate; and iron preparations significantly reduce absorption—administer at least 2 hours before or after Lquin. May enhance effects of warfarin—monitor INR closely. QT-prolonging agents (antiarrhythmics, antipsychotics) should be used with caution. Nonsteroidal anti-inflammatory drugs may increase CNS stimulation risk.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for the missed one. Maintain the regular dosing schedule. If multiple doses are missed, contact healthcare provider for guidance.

Overdose

Symptoms may include dizziness, tremors, seizures, and gastrointestinal distress. Management includes ECG monitoring for QT prolongation and symptomatic support. Hemodialysis removes approximately 10% of the drug. There is no specific antidote; gastric lavage may be considered if presented early after ingestion.

Storage

Store at room temperature (15–30°C) in original container, protected from light and moisture. Keep out of reach of children. Do not use if tablets are discolored or show signs of deterioration. IV solutions should be used immediately after preparation; discard any unused portion.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis and treatment recommendations. Dosage and administration should be determined by a qualified physician based on individual patient factors.

Reviews

Clinical studies demonstrate Lquin’s efficacy with clinical cure rates of 85–92% for respiratory infections and 80–88% for complicated UTIs. Physicians report reliable performance in hospital settings, particularly for pneumonia treatment. Some patients note gastrointestinal side effects but generally report satisfactory tolerance when taken with food. The once-daily dosing is frequently cited as a significant advantage over multiple-dose alternatives.