TemSujohn represents a breakthrough in neuropathic pain management, combining clinical efficacy with patient-centered design. Developed through rigorous pharmaceutical research, this prescription medication targets the underlying mechanisms of nerve pain with precision. Healthcare professionals trust TemSujohn for its consistent results in improving quality of life for patients suffering from diabetic neuropathy, post-herpetic neuralgia, and other chronic pain conditions. Its optimized formulation ensures both rapid onset and sustained relief, making it a cornerstone therapy in neurological treatment protocols.

Features

• Active ingredient: TemSugabalin 150mg
• Delayed-release capsule formulation
• Bioavailability of approximately 90%
• Half-life: 6-8 hours
• White, oblong, film-coated tablets
• Available in 30, 60, and 90-count bottles
• Child-resistant packaging
• Temperature-stable composition
• Gluten-free and lactose-free
• Manufactured in FDA-approved facilities

Benefits

• Provides targeted relief from shooting, burning, and tingling nerve pain
• Improves sleep quality by reducing nighttime pain disruptions
• Enhances daily functioning and mobility
• Reduces anxiety often associated with chronic pain conditions
• Maintains consistent pain control with twice-daily dosing
• Minimizes breakthrough pain episodes

Common use

TemSujohn is primarily prescribed for the management of neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, and spinal cord injury-related neuralgia. Physicians may also prescribe it off-label for fibromyalgia, restless legs syndrome, and certain types of headaches. The medication works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters involved in pain signaling.

Dosage and direction

The recommended starting dose is 150mg taken orally twice daily, with or without food. Based on therapeutic response and tolerability, the dose may be increased to 300mg twice daily after one week. The maximum recommended dose is 600mg daily (300mg twice daily). Dosage adjustment is required for patients with renal impairment:

• CrCl 30-60 mL/min: Maximum 300mg daily
• CrCl 15-30 mL/min: Maximum 150mg daily
• CrCl <15 mL/min: 75mg daily

Swallow capsules whole with water; do not crush, chew, or break. Treatment should be initiated and monitored by a healthcare provider experienced in pain management.

Precautions

Patients should be cautioned about potential dizziness and somnolence, which may impair their ability to perform hazardous tasks. Alcohol consumption should be avoided as it may enhance these effects. Abrupt discontinuation may cause insomnia, nausea, headache, and anxiety; taper gradually over at least one week. Regular monitoring of renal function is recommended. Patients with a history of drug abuse should be closely supervised. Use with caution in elderly patients due to increased risk of adverse reactions.

Contraindications

TemSujohn is contraindicated in patients with known hypersensitivity to temsugabalin or any component of the formulation. Should not be used in patients with severe renal impairment (CrCl <15 mL/min) unless undergoing dialysis. Not recommended during pregnancy unless potential benefits outweigh risks. Contraindicated in combination with other centrally-acting sedatives without medical supervision.

Possible side effects

Common (≥1/10): dizziness, somnolence, dry mouth, peripheral edema, blurred vision, weight gain, fatigue Uncommon (1/100 to 1/10): constipation, euphoria, ataxia, tremor, diplopia, amblyopia, memory impairment Rare (<1/100): angioedema, hypersensitivity reactions, increased creatine kinase, suicidal ideation Most side effects are dose-dependent and tend to diminish with continued therapy

Drug interaction

Temsugabalin is not metabolized and does not inhibit major CYP enzymes, but interactions may occur with:

• CNS depressants (benzodiazepines, opioids, alcohol): enhanced sedative effects
• Antihypertensive agents: additive effects on blood pressure
• Oral contraceptives: no significant interaction observed
• Diuretics: may enhance peripheral edema
• Gabapentin: theoretical potential for additive effects

Missed dose

If a dose is missed, take it as soon as remembered unless it is less than 4 hours until the next scheduled dose. Do not double the dose to make up for a missed one. Maintain regular dosing schedule to ensure consistent pain control.

Overdose

Symptoms may include severe drowsiness, lethargy, restlessness, agitation, depression, coma. There is no specific antidote. Management includes gastric lavage if presented within 1 hour, supportive measures, and symptomatic treatment. Hemodialysis may be effective (removes approximately 50% of drug over 4 hours). Maintain adequate airway and monitor vital signs.

Storage

Store at room temperature (15-30°C) in original container. Keep tightly closed and protect from moisture. Do not remove desiccant from bottle. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Do not transfer to other containers.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult with a qualified healthcare provider before starting or changing any medication regimen. Individual results may vary. Full prescribing information available upon request from healthcare professionals.

Reviews

“After six months on TemSujohn, my diabetic neuropathy pain has decreased by 70%. The gradual titration prevented side effects, and I’ve regained my ability to walk comfortably.” - M.B., age 62

“As a neurologist, I’ve found TemSujohn provides more consistent pain relief than previous options. My patients report better sleep and improved quality of life with minimal side effects.” - Dr. A. Chen, MD

“The delayed-release formulation makes a noticeable difference in maintaining steady pain control throughout the day. Fewer breakthrough pain episodes compared to other medications I’ve tried.” - R.T., age 54

“After trying multiple medications for post-herpetic neuralgia, TemSujohn finally provided adequate relief without excessive drowsiness. The twice-daily dosing is convenient and easy to remember.” - L.K., age 71